Retinal Degenerative Diseases: Mechanisms and Experimental Therapy

Retinal Degenerative Diseases: Mechanisms and Experimental Therapy- Ebook Instant Download/Delivery ISBN(s): 9783031276804,3031276809,9783319754024, 3319754025

Product details:

• ISBN 10: 3319754025
• ISBN 13: 9783319754024
• Author: John D. Ash , Eric Pierce , Robert E. Anderson , Catherine Bowes Rickman , Joe G. Hollyfield , Christian Grimm

Table contents:

Part I. Age-Related Macular Degeneration (AMD)

1. Oxidative Stress Regulation and DJ-1 Function in the Retinal Pigment Epithelium: Implications for AMD

2. Mitochondria: Potential Targets for Protection in Age-Related Macular Degeneration

3. Toll-Like Receptors and Age-Related Macular Degeneration

4. Alterations in Extracellular Matrix/Bruch’s Membrane Can Cause the Activation of the Alternative Complement Pathway via Tick-Over

5. MicroRNA as Therapeutics for Age-Related Macular Degeneration

6. Anaphylatoxin Signaling in Retinal Pigment and Choroidal Endothelial Cells: Characteristics and Relevance to Age-Related Macular Degeneration

7. Estimations of Retinal Blue-Light Irradiance Values and Melatonin Suppression Indices Through Clear and Yellow-Tinted Intraocular Lenses

8. Co-Expression of Wild-Type and Mutant S163R C1QTNF5 in Retinal Pigment Epithelium

Part II. Gene Therapies

9. Mini-Review: Cell Type-Specific Optogenetic Vision Restoration Approaches

10. Mutation-Independent Gene Therapies for Rod-Cone Dystrophies

11. Antisense Oligonucleotide-Based Splice Correction of a Deep-Intronic Mutation in CHM Underlying Choroideremia

12. Gene Therapy Approaches to Treat the Neurodegeneration and Visual Failure in Neuronal Ceroid Lipofuscinoses

13. Success of Gene Therapy in Late-Stage Treatment

14. Optimizing Non-viral Gene Therapy Vectors for Delivery to Photoreceptors and Retinal Pigment Epithelial Cells

15. Nanoparticles as Delivery Vehicles for the Treatment of Retinal Degenerative Diseases

16. Overexpression of Type 3 Iodothyronine Deiodinase Reduces Cone Death in the Leber Congenital Amaurosis Model Mice

Part III. In-Vivo Diagnostics for Structure and Function

17. In Vivo Functional Imaging of Retinal Neurons Using Red and Green Fluorescent Calcium Indicators

18. Optimizing ERG Measures of Scotopic and Photopic Critical Flicker Frequency

19. Repeatability and Reproducibility of In Vivo Cone Density Measurements in the Adult Zebrafish Retina

20. Normative Retinal Thicknesses in Common Animal Models of Eye Disease Using Spectral Domain Optical Coherence Tomography

21. A Novel Approach for Integrating AF-SLO and SDOCT Imaging Data Demonstrates the Ability to Identify Early Retinal Abnormalities in Mutant Mice and Evaluate the Effects of Genetic and Pharmacological Manipulation

Part IV. Inflammation and Angiogenesis

22. The Role of Hypoxia, Hypoxia-Inducible Factor (HIF), and VEGF in Retinal Angiomatous Proliferation

23. Neuroinflammation in Retinitis Pigmentosa, Diabetic Retinopathy, and Age-Related Macular Degeneration: A Minireview

24. Autoimmune Retinopathy: An Immunologic Cellular-Driven Disorder

25. Inflammation-Induced Photoreceptor Cell Death

26. Sall1 Regulates Microglial Morphology Cell Autonomously in the Developing Retina

Part V. Inherited Retinal Degenerations

27. Whole-Exome Sequencing Identifies Novel Variants that Co-segregates with Autosomal Recessive Retinal Degeneration in a Pakistani Pedigree

28. Identification of Novel Deletions as the Underlying Cause of Retinal Degeneration in Two Pedigrees

29. Molecular Findings in Families with an Initial Diagnose of Autosomal Dominant Retinitis Pigmentosa (adRP)

30. Pleiotropic Effects of Risk Factors in Age-Related Macular Degeneration and Seemingly Unrelated Complex Diseases

31. Mapping of Canine Models of Inherited Retinal Diseases

32. A Mini-Review: Leber Congenital Amaurosis: Identification of Disease-Causing Variants and Personalised Therapies

Part VI. Mechanisms of Degeneration

33. Role of Fibulins 2 and 5 in Retinal Development and Maintenance

34. Identifying Key Networks Linked to Light-Independent Photoreceptor Degeneration in Visual Arrestin 1 Knockout Mice

35. How Excessive cGMP Impacts Metabolic Proteins in Retinas at the Onset of Degeneration

36. Protein Carbonylation-Dependent Photoreceptor Cell Death Induced by N-Methyl-N-nitrosourea in Mice

37. Müller Glia Reactivity and Development of Gliosis in Response to Pathological Conditions

38. Underdeveloped RPE Apical Domain Underlies Lesion Formation in Canine Bestrophinopathies

39. Binary Function of ARL3-GTP Revealed by Gene Knockouts

40. Do cGMP Levels Drive the Speed of Photoreceptor Degeneration?

41. Early Endosome Morphology in Health and Disease

42. The Retinal Circadian Clock and Photoreceptor Viability

43. The Role of c-Jun N-Terminal Kinase (JNK) in Retinal Degeneration and Vision Loss

44. The Evaluation of BMI1 Posttranslational Modifications During Retinal Degeneration to Understand BMI1 Action on Photoreceptor Death Execution

45. Primary Rod and Cone Degeneration Is Prevented by HDAC Inhibition

46. Impact of MCT1 Haploinsufficiency on the Mouse Retina

47. The Leber Congenital Amaurosis-Linked Protein AIPL1 and Its Critical Role in Photoreceptors

48. Alternative Splicing for Activation of Coagulation Factor XIII-A in the Fish Retina After Optic Nerve Injury

49. Bisretinoid Photodegradation Is Likely Not a Good Thing

50. Further Characterization of the Predominant Inner Retinal Degeneration of Aging Cln3 Δex7/8 Knock-In Mice

51. Differential Exon Expression in a Large Family of Retinal Genes Is Regulated by a Single Trans Locus

52. Molecular Chaperone ERp29: A Potential Target for Cellular Protection in Retinal and Neurodegenerative Diseases

53. The Role of Microbiota in Retinal Disease

Part VII. Neuroprotection

54. Current Pharmacological Concepts in the Treatment of the Retinitis Pigmentosa

55. Valproic Acid Inhibits Human Retinal Pigment Epithelial (hRPE) Cell Proliferation Via a P38 MAPK Signaling Mechanism

56. Pigment Epithelium-derived Factor Protects Retinal Pigment Epithelial Cells Against Cytotoxicity “In Vitro”

57. Brain-Derived Neurotrophic Factor as a Treatment Option for Retinal Degeneration

58. VEGF as a Trophic Factor for Müller Glia in Hypoxic Retinal Diseases

59. Müller Cell Biological Processes Associated with Leukemia Inhibitory Factor Expression

60. Retbindin Is Capable of Protecting Photoreceptors from Flavin-Sensitized Light-Mediated Cell Death In Vitro

61. Constitutive Activation Mutant mTOR Promote Cone Survival in Retinitis Pigmentosa Mice

62. Maintaining Cone Function in Rod-Cone Dystrophies

63. PKG-Dependent Cell Death in 661W Cone Photoreceptor-like Cell Cultures (Experimental Study)

Part VIII. Retinal Cell Biology

64. More Than Meets the Eye: Current Understanding of RPGR Function

65. Polarized Exosome Release from the Retinal Pigmented Epithelium

66. The Impact of Adherens and Tight Junctions on Physiological Function and Pathological Changes in the Retina

67. TRPV4 Does Not Regulate the Distal Retinal Light Response

68. Role of Sirtuins in Retinal Function Under Basal Conditions

69. The Retinol-Binding Protein Receptor 2 (Rbpr2) Is Required for Photoreceptor Survival and Visual Function in the Zebrafish

70. Opposite Roles of MerTK Ligands Gas6 and Protein S During Retinal Phagocytosis

71. Redundant and Nonredundant Functions of Akt Isoforms in the Retina

72. Photoreceptor Outer Segment Isolation from a Single Canine Retina for RPE Phagocytosis Assay

73. Preservation of Photoreceptor Nanostructure for Electron Tomography Using Transcardiac Perfusion Followed by High-Pressure Freezing and Freeze-Substitution

74. Microtubule-Associated Protein 1 Light Chain 3 (LC3) Isoforms in RPE and Retina

Part IX. Stem Cells

75. The iPSc-Derived Retinal Tissue as a Tool to Study Growth Factor Production in the Eye

76. Stem Cell-Based RPE Therapy for Retinal Diseases: Engineering 3D Tissues Amenable for Regenerative Medicine

77. Validation of iPS Cell-Derived RPE Tissue in Animal Models

78. Cell Transplantation for Retinal Degeneration: Transition from Rodent to Nonhuman Primate Models

79. Talaumidin Promotes Neurite Outgrowth of Staurosporine-Differentiated RGC-5 Cells Through PI3K/Akt-Dependent Pathways

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