Epigenetics in Precision Medicine 1st Edition by Jose Luis Garcia Gimenez B09LSZY6MG

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ISBN-10 ‏ : ‎B09LSZY6MG

Author:   Jose Luis Garcia-Gimenez 

In recent years, knowledge of epigenetic mechanisms underlying disease onset and progression has proven crucial for the development of novel early diagnosis and prognosis biomarkers for patient stratification and precision medicine. Epigenetics in Precision Medicine, a new volume in the Translational Epigenetics series, provides a thorough discussion and overview of current developments in clinical epigenetics with special emphasis on epigenetic biomarkers that can be used for clinical diagnosis, prognosis, patient stratification, and treatment monitoring. Disease types discussed include cancer, metabolic disorders, neurodegenerative diseases, bone disease, and immune-related disorders. The book examines the challenges of advancing epigenetics research and translating findings to the clinic and drug discovery in each of these areas, as well as current solutions; chapter authors discuss how to leverage epigenomic technologies, applications, and tools, such as next-generation sequencing, to discover new epigenetic biomarkers in disease and drug studies.
Epigenetics in Precision Medicine focuses on complex epigenetic mechanisms in several pathologies, and explores how epigenetics can power the advance of precision medicine, not only by improving in vitro diagnostic and prognostic tools, but by providing new therapeutic approaches to treat human disease.

Epigenetics in Precision Medicine 1st Table of contents:

Chapter 1: Perspectives and future directions of translational epigenetics in personalized and precision medicine
Abstract
Introduction
Diagnostic, prognostic, and therapeutic applications of epigenetics in precision medicine
Epigenetic-based therapies
Conclusions and perspective
Chapter 2: Translational epigenetics in precision medicine of colorectal cancer
Abstract
Introduction
Potential epigenetic biomarkers for CRC
Epigenetic-based IVD test for CRC
Conclusions and future prospects
Chapter 3: Epigenetics in precision medicine of breast cancer
Abstract
Introduction
Epigenetics in breast carcinogenesis
DNA methylation as a biomarker for breast cancer
Histone posttranslational modifications as a biomarker for breast cancer
ncRNAs as a biomarker for breast cancer
Dietary epigenetic modulators in precision medicine of breast cancer
Conclusions
Glossary
Chapter 4: Epigenetics and precision medicine in prostate cancer
Abstract
Acknowledgments
Introduction
Prostate cancer epigenetics
Epigenetic therapies in prostate cancer
Epigenetic biomarkers of treatment response
Conclusion
Chapter 5: Epigenetics and precision medicine in lung cancer
Abstract
Introduction
Epigenetics of lung cancer
Diagnostic, prognostic, and therapeutic applications of epigenetics in lung cancer
Drug response and therapeutics
Conclusions and perspective
Chapter 6: Epigenetics and precision medicine in bone and soft tissue sarcomas
Abstract
Introduction
Osteosarcoma
Ewing sarcoma
Undifferentiated pleomorphic sarcoma
Synovial sarcoma
Rhabdomyosarcoma
Leiomyosarcoma
Liposarcoma
Malignant peripheral nerve sheath tumor
Fibrosarcoma
Conclusions
Chapter 7: Epigenetics and precision medicine in skin diseases
Abstract
Introduction
Inflammatory skin diseases
Connective tissue diseases
Skin neoplasms
Conclusions
Chapter 8: Epigenetic biomarker and drug development in gynecological cancers
Abstract
Cervical cancer
Endometrial cancer
Ovarian cancer
Conclusion
Chapter 9: Epigenetics in precision medicine of pancreatic cancer
Abstract
Introduction
Epigenetics of pancreatic cancer
Diagnostic, prognostic, and therapeutic applications of epigenetics in pancreatic cancer
Conclusions and perspective
Chapter 10: Epigenetics and personalized medicine of brain cancer
Abstract
Ethics approval and consent to participate
Consent for publication
Availability of data and material
Competing interests
Conflict of interest
Funding
Acknowledgments
Introduction
Epigenomics: An introduction
Comprehending epigenetics
Targeted and personalized therapies
Conclusions
Glossary
Chapter 11: Epigenetics and precision medicine in diabetes and obesity prevention and management
Abstract
Introduction
Routine diagnostic biomarkers for obesity and T2D
Epigenetic regulation and disease
Epigenetic mechanisms
Precision medicine and epigenetic marks in metabolic disorders
Future remarks and conclusion
Chapter 12: Epigenetics in precision medicine of cardiovascular disease
Abstract
Cardiovascular disease
Biomarkers
Epigenetic biomarkers: Noncoding RNAs
Most relevant noncoding RNA subclasses in the field of biomarkers
Noncoding RNAs as diagnostic biomarkers of cardiovascular disease
Noncoding RNAs as prognostic biomarkers of cardiovascular disease
Noncoding RNAs in biomarker-guided therapy of cardiovascular disease
Defining clinical phenotypes: Noncoding RNAs and decision tree learning
Conclusions
Chapter 13: Sperm epigenetics: The future of precision medicine in male infertility
Abstract
Disclosures
Introduction
Epigenetics: Background and history
Histone posttranslational modifications
DNA methylation
Noncoding RNA
Epigenetics and fertility
Using epigenetic data in predictive modeling to identify and treat male fertility
Conclusions and future perspective
Chapter 14: Epigenetic in precision medicine in autoimmune and inflammatory-mediated disorders
Abstract
Introduction
Epigenetic bases of autoimmune inflammatory-related diseases
Conclusions and perspective
Chapter 15: Epigenetics and precision medicine in allergic diseases
Abstract
Introduction
Precision medicine in allergic diseases
The epigenome as a target for personalized treatment
Conclusions
Chapter 16: Epigenetics in spine curvature disorders
Abstract
Introduction
Epigenetics in bone metabolism associated to spine deformity
DNA methylation
Noncoding RNAs
Role of miRNAs in AIS
Role of miRNAs in DS
Epigenetic biomarkers in scoliosis precision medicine
DNA methylation biomarkers in AIS precision medicine
miRNAs biomarkers in AIS precision medicine
Conclusions and future prospects
Chapter 17: Methylated circulating tumor DNA biomarkers for the blood-based detection of cancer signals
Abstract
Introduction
The public health burden of cancer and the need for minimally invasive tests for cancer detection
Circulating tumor DNA as a biomarker for the detection of cancer signals
Choice of somatic sequence mutation or DNA methylation as ctDNA biomarkers
Characteristics and composition of cfDNA and ctDNA
ctDNA detection technologies
Best preanalytical practices for obtaining high-quality cfDNA templates
Blood collection and preanalytical variables
Cell-free DNA isolation and quality control
Sodium bisulfite conversion of cfDNA for DNA methylation analyses
Cell-free DNA assay types
Real-time PCR-based assays for targeted loci
Next-generation sequencing (NGS)-based assays
“Real-world” applications of cfDNA technology to the detection of cancer signals
Early detection of cancer via population-based screening
Development of multicancer screening test based on methylated ctDNA profiles
The Galleri test by GRAIL Inc
Application of ctDNA technology in oncology for the clinical management of cancer patients
Utility of ctDNA testing for monitoring tumor burden in cancer patients
Benefits of the detection of molecular residual disease, recurrence, and tumor burden in the setting of colorectal cancer
Personalized NGS-based assay for the detection of minimal residual disease and cancer recurrence
Methylated ctDNA test for the detection of minimal residual disease and recurrence of CRC
Liquid biopsy
Liquid biopsy for the prediction of response to treatment
Conclusions and future directions
Chapter 18: Dietary regulation of miRNA in precision medicine of lung cancer
Abstract
Introduction
Biogenesis of miRNA
Role of miRNA in lung cancer progression
Role of miRNAs in lung cancer therapeutics
Dietary regulation of miRNA in lung cancer
Conclusion and future perspective
Glossary
Chapter 19: Epigenetic biomarkers in male infertility and its potential use in assisted reproductive technology
Abstract
Introduction
Epigenetics in spermatogenesis and male infertility
The potential of epigenetics to improve clinical management of male infertility
Conclusions and future prospects

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