Biophysical Characterization of Proteins in Developing Biopharmaceuticals 2nd Edition Damian 0444641742 9780444641748

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Product details:

• ISBN 10: 0444641742
• ISBN 13: 9780444641748
• Author: Damian J. Houde

Biophysical Characterization of Proteins in Developing Biopharmaceuticals, Second Edition, presents the latest on the analysis and characterization of the higher-order structure (HOS) or conformation of protein based drugs. Starting from the very basics of protein structure, this book explains the best way to achieve this goal using key methods commonly employed in the biopharmaceutical industry. This book will help today’s industrial scientists plan a career in this industry and successfully implement these biophysical methodologies. This updated edition has been fully revised, with new chapters focusing on the use of chromatography and electrophoresis and the biophysical characterization of very large biopharmaceuticals.

In addition, best practices of applying statistical analysis to biophysical characterization data is included, along with practical issues associated with the concept of a biopharmaceutical’s developability and the technical decision-making process needed when dealing with biophysical characterization data.

Table of contents:

1. Chapter 1. The complexity of protein structure and the challenges it poses in developing biopharmaceuticals
2. Chapter 2. Biophysical characterization and its role in the biopharmaceutical industry
3. Chapter 3. Biopharmaceutical industry’s biophysical toolbox
4. Chapter 4. An introduction and hierarchical organization of the biophysical tool in section II
5. Chapter 5. UV-absorbance, fluorescence and FT-IR spectroscopy in biopharmaceutical development
6. Chapter 6. Biopharmaceutical applications of protein characterisation by circular dichroism spectroscopy
7. Chapter 7. Size-exclusion chromatography (SEC) in biopharmaceutical process development
8. Chapter 8. Scattering techniques for the characterization of biopharmaceuticals
9. Chapter 9. Characterizing biopharmaceuticals using analytical ultracentrifugation
10. Chapter 10. Submicrometer, micrometer and visible particle analysis in biopharmaceutical research and development
11. Chapter 11. Differential scanning calorimetry in the biopharmaceutical sciences
12. Chapter 12. Biophysical mass spectrometry for biopharmaceutical process development: focus on
13. Chapter 13. One- and two-dimensional NMR techniques
14. Chapter 14. Chromatography (other than size-exclusion chromatography) and electrophoresis
15. III. Concluding remarks on the biophysical characterization of biopharmaceuticals
16. Chapter 15. Challenges with the biophysical characterization of complex (multi-chain assembly, chemically modified
17. Chapter 16. The rigor of statistical analysis in assessing biophysical data: A lifecycle approach
18. Chapter 17. Developability in biophysical characterization
19. Chapter 18. Technical decision making using biophysical data
20. Chapter 19. Biophysical characterization: an integral part of the “totality

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