Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters: Concepts, Methods and Translational Sciences 2nd Edition Shuguang Ma (Editor)

Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters: Concepts, Methods and Translational Sciences – Ebook Instant Download/Delivery ISBN(s): 9780128200186,0128200189

Product details:

• ISBN-10 ‏ : ‎ 0128200189
• ISBN-13 ‏ : ‎ 978-0128200186
• Author: Shuguang Ma, Swapan Chowdhury

Identification and Quantification of Drugs, Metabolites, Drug Metabolizing Enzymes, and Transporters, Second Edition, is completely updated to provide an overview of the last decade’s numerous advances in analytical technologies for detection and quantification of drugs, metabolites, and biomarkers. This new edition goes beyond LC-MS and features all-new chapters on how to evaluate drug absorption, distribution, metabolism, and excretion, potential for hepatic and renal toxicity, immunogenicity of biotherapeutics and translational tools for predicting human dosage, safety and efficacy of small molecules and biologics. This book will be an important handbook and desk reference for pharmacologists, toxicologists, clinical scientists, and students interested in the fields of pharmacology, biochemistry, and drug metabolism.

Table contents:

Part I: Techniques for Identifying and Quantifying Drugs and Metabolites

1. Bioanalysis of Small and Large Molecule Drugs, Metabolites, and Biomarkers by LC-MS

2. Recent advances in mass spectrometric and other analytical techniques for the identification of drug metabolites

3. High-resolution mass spectrometry-based data acquisition and data mining technologies for detecting and characterizing drug metabolites and herbal medicine components

4. Metabolite Generation and Metabolite Characterization by NMR

5. Application of SFC for bioanalysis

6. AMS in drug development: Exploring the current utility of AMS and future opportunities for Absolute Bioavailability and ADME investigations

Part II: Drug Metabolism Enzymes, Transporters and Drug-Drug Interaction

7. Using in vitro methods to determine P450s responsible for metabolism and discrimination from other oxidative pathways

8. Evaluation of the clearance mechanism of non-CYP enzymes mediated drug metabolism and DDI as a victim drug

9. In vitro Characterization and In Vitro to In Vivo Predictions of Drug-Drug Interactions

10. Role of Transporters in drug disposition and Drug-drug Interactions

11. Mechanisms and Clinical Relevance of Pharmacokinetic-based Clinical Drug-drug Interactions for Drugs Recently Approved by the U.S. Food and Drug Administration

12. Quantifying drug metabolism enzymes and transporters by LC-MS/MS proteomics

13. Protein Drug-Drug Interactions for Disease Modifying Modalities

 

Part III: Strategy Related to Drug Metabolism and Safety

14. Metabolites in safety testing (MIST)

15. The Use of Stable Isotopes in Drug Metabolism Studies

16. Assessment of Stereoselectivity in Pharmacology, Toxicology and Drug Metabolism

17. Progress of De-Risking Strategies for Drug-Induced Liver Injury (DILI) In the Last Two Decades

18. Predictive and Translational Models for Renal Drug Safety Evaluation

19. Immunogenicity: An Introduction to Its Role in the Safety and Efficacy of Biotherapeutics

 

Part IV: Translational Sciences

20. Application of Genetically-Modified Rodent Models in Drug Discovery and Development　for Translation of Clinical ADME Properties

21. Advances in CRISPR Technologies Enable Novel in vitro Tools for ADME Studies

22. In vitro-In vivo Extrapolation of Human Hepatic and Renal Clearance

23 The Role of Mathematical Modeling in Translational Science

24. PK/PD Driven Starting and Effective Human Dose Determination for Immuno-Oncology Drugs

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