Organic Synthesis Using Biocatalysis 1st Edition by Animesh Goswami, Jon Stewart 0124115187 978-0124115187

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ISBN-10 ‏ : ‎ 0124115187

ISBN-13 ‏ : ‎ 978-0124115187

Author:   Animesh Goswami, Jon D. Stewart

Organic Synthesis Using Biocatalysis provides a concise background on the application of biocatalysis for the synthesis of organic compounds, including the important biocatalytic reactions and application of biocatalysis for the synthesis of organic compounds in pharmaceutical and non-pharmaceutical areas.

The book provides recipes for carrying out various biocatalytic reactions, helping both newcomers and non-experts use these methodologies. It is written by experts in their fields, and provides both a current status and future prospects of biocatalysis in the synthesis of organic molecules.

Organic Synthesis Using Biocatalysis 1st Table of contents:

List of Contributors
Chapter 1: Introduction, Types of Reactions, and Sources of Biocatalysts
Abstract
1. Introduction
2. Definition of biocatalysis
3. Scope of this book
4. Key benefits of employing enzymes in synthesis
5. Mechanism and kinetics of enzyme-catalyzed reactions
6. Types of enzyme-catalyzed reactions commonly used in biocatalysis
7. Sources of biocatalysts
8. Types of enzyme preparation
9. Availability of enzymes for biocatalysis
Chapter 2: Practical and Engineering Aspects of Running Enzyme Reactions
Abstract
1. Introduction
2. Availability of an efficient enzyme as a catalyst: screening and protein engineering
3. The role of cofactors and practical concepts for their in situ regeneration
4. Enzyme formulation
5. Immobilization and reuse of catalysts
6. Reagent/Substrate engineering
7. Reaction media engineering
8. Reaction engineering: batch versus continuously running processes
9. Summary
Chapter 3: Biocatalysis in Organic Solvents, Supercritical Fluids and Ionic Liquids
Abstract
1. Introduction
2. Key attributes of reactions in nonaqueous solvents
3. Kinds of nonaqueous solvents used for biocatalysis
4. Solubility of enzymes, substrates, and products in nonaqueous solvents
5. Stability of enzymes in nonaqueous solvents
6. Selection of nonaqueous solvents for a desired reaction
7. Examples of reactions in organic solvents
8. Examples of reactions in aqueous – organic biphasic systems
9. Examples of reactions in supercritical fluids
10. Examples of reactions in aqueous – supercritical fluids biphasic systems
11. Examples of reactions in ionic liquids
12. Examples of reactions in aqueous – ionic liquids biphasic systems
13. Examples of reactions in ionic liquids – supercritical fluids biphasic systems
14. Conclusions
Chapter 4: Enzyme Immobilization for Organic Synthesis
Abstract
1. Introduction
2. Immobilization techniques
3. Specific examples of immobilized biocatalysts
Chapter 5: Hydrolysis and Formation of Carboxylic Acid and Alcohol Derivatives
Abstract
1. Introduction – hydrolases commonly used in organic synthesis
2. Choosing a hydrolase – substrate specificity and enantioselectivity
3. Enantiopure compounds: resolutions, desymmetrizations, and dynamic kinetic resolutions
4. Choosing reaction conditions – water or organic solvent
5. Example reactions
Chapter 6: Modern Biocatalytic Ketone Reduction
Abstract
1. Introduction
2. Mechanism of enzymatic ketone reduction
3. Recent bioreduction examples
4. Immobilization of CRED enzymes and membrane applications
5. Ionic liquids and CRED enzymes
6. Future outlook
7. Practical examples
8. Conclusions
Chapter 7: Organic Synthesis with Amino Acid Dehydrogenases, Transaminases, Amine Oxidases, and Amine Dehydrogenases
Abstract
1. Introduction
2. Amino acid dehydrogenases
3. Transaminases
4. Amine oxidase
5. Amine dehydrogenases
Acknowledgment
Chapter 8: Biocatalysis for Organic Chemists: Hydroxylations
Abstract
1. Introduction
2. Cytochrome P450s
3. Examples of P450-catalysed biotransformations
4. Flavin-dependent hydroxylases
5. 2-Oxoglutarate dependent hydroxylases
6. Conclusions
Chapter 9: Miscellaneous Key Non-C―C Bond Forming Enzyme Reactions
Abstract
1. Nitrile hydratases
2. Nitrilases
3. Hydantoinases and carbamoylases
4. Epoxide hydrolase for epoxide and diol formation
5. Dehalogenase
6. Enoate reductases
7. Baeyer–Villiger monooxygenases
8. Dihydroxylation of aromatic compounds
9. Experimental procedures
Chapter 10: Enzymatic C―C Bond Formation
Abstract
1. Hydroxynitrile lyases
2. Carbon–carbon bond formation using thiamin diphosphate (ThDP)-dependent carboligases
3. Enzymatic aldol additions
Chapter 11: Applications of Biocatalysis for Pharmaceuticals and Chemicals
Abstract
1. Introduction
2. Enzymatic enantioselective hydrolysis and desymmetrization
3. Enzymatic esterification, transesterification, and amidation
4. Enzymatic acylation
5. Ketoreductases and chiral alcohols
6. Enzymatic transamination reactions
7. Enzymatic reductive amination
8. Enzymatic hydroxylation
9. Application of biocatalysis in basic and specialty Chemicals
10. Conclusions
Acknowledgments
Chapter 12: Future of Biocatalysis in the Synthesis of Organic Compounds
Abstract
Subject Index

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