A Roadmap to Nonhematopoietic Stem Cell-Based Therapeutics From the Bench to the Clinic Xiao-Dong Chen

A Roadmap to Nonhematopoietic Stem Cell-Based Therapeutics From the Bench to the Clinic – Ebook Instant Download/Delivery ISBN(s): 9780128119204,0128119209

Product details:

• ISBN-10 ‏ : ‎ 0128119209
• ISBN-13 ‏ : ‎ 978-0128119204
• Author(s): Xiao-Dong Chen

A Roadmap to Non-hematopoietic Stem Cell-Based Therapeutics: From the Bench to the Clinic is a resource that provides an overview of the principles of stem cell therapy, the promises and challenges of using stem cells for treating various clinical conditions, and future perspectives. The overall goal is to facilitate the translation of basic research on stem cells to clinical applications. The properties of stem cells from various sources are reviewed and the advantages and disadvantages of each for clinical use are discussed. Modifying stem cell properties through preconditioning strategies using physical, chemical, genetic, and molecular manipulation to improve cell survival, increase cell differentiation potential, enhance production of paracrine factors, and facilitate homing to the site of injury or disease upon transplantation are reviewed. Various routes of stem cell administration and dosing, and the duration of effects, are explored. Individual chapters are written by experts in the field and focus on the use of stem cells in treating various degenerative diseases, autoimmune diseases, wound healing, cardiovascular disease, spinal cord injury, oral and dental diseases, and skeletal disorders. Finally, experts in the regulatory arena discuss mechanisms used in different countries for approving the use of stem cells to treat diseases and many common issues that are typically encountered while seeking approval for this class of therapeutic agent.

Table contents:

Part I. Principles & Concepts
Chapter 1. What Can We Learn From This Book?

Chapter 2. Features of Mesenchymal Stem Cells

Chapter 3. Maintenance and Culture of MSCs
Chapter 4. Manufacturing Mesenchymal Stromal Cell Banks

Part II. Promises and Challenges of MSC-Based Therapies
Chapter 5. Mesenchymal Stem Cell-Based Therapy of Osteoarthritis: Current Clinical Developments and Future Therapeutic Strategies

Chapter 6. Mesenchymal Stem Cell Therapy in Graft Versus Host Disease

Chapter 7. Systemic Lupus Erythematosus

Chapter 8. Mesenchymal Stem Cell–Based Therapies for Repair and Regeneration of Skin Wounds

Chapter 9. Myocardial Infarction

Chapter 10. Bone Marrow Mesenchymal Stem Cells as a New Therapeutic Approach for Diabetes Mellitus

Chapter 11. Mesenchymal Stem Cell–Based Therapy for Chronic Kidney Disease

Chapter 12. Promises and Challenges of MSC-Based Therapies: Parkinson Disease and Parkinsonism

Chapter 13. Spinal Cord Injury

Chapter 14. Stem Cell–Based Restoration of Salivary Gland Function

Chapter 15. Tooth and Dental Pulp Regeneration

Part III. Future Perspectives
Chapter 16. MSCs as Biological Drugs

Chapter 17. Mesenchymal Stem Cell–Derived Products for Tissue Repair and Regeneration

Chapter 18. Use of MSCs in Antiaging Strategies

Chapter 19. Regulatory Developments for Nonhematopoietic Stem Cell Therapeutics: Perspectives From the EU, the USA, Japan, China, India,

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