(Ebook PDF) Advances in Protein Chemistry and Structural Biology Protein Misfolding 1st edition by Rossen Donev 0128177500 978-0128177501 full chapters

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ISBN-10 ‏ : ‎ 0128177500

ISBN-13 ‏ : ‎ 978-0128177501

Author : Rossen Donev

Protein Misfolding, Volume 118, covers the wide spectrum of diseases and disorders that are attributed to protein misfolding, including degenerative and neurodegenerative, cardiovascular, renal, glaucoma, cancer, cystic fibrosis, Gaucher’s disease, and many others. Specific chapters cover Mass spectrometric approaches for profiling protein folding and stability, Biomembranes, a key player in protein misfolding, how Genetic and environmental factors interact to disrupt proteostasis and trigger protein misfolding diseases, Formation of oligomers and large amorphous aggregates by intrinsically disordered proteins, Protein misfolding in ER stress with applications to cardiovascular and renal disease, and much more.

Advances in Protein Chemistry and Structural Biology: Protein Misfolding 1st Table of contents:

1 Introduction
2 Isolation of protein complexes
3 Proteomics enters the PPI field
4 Whole proteome screening for PPIs
5 Protein-protein interaction databases
6 Challenges in generating global PPI maps
7 Conclusions
References
Chapter Two: Functional proteomics based on protein microarray technology for biomedical research
Abstract
1 Introduction
2 Proteomic technologies
3 Microarrays applications
4 Conclusions and future perspectives
References
Chapter Three: Understanding functions of eEF1 translation elongation factors beyond translation. A proteomic approach
Abstract
1 Human translation elongation factors
2 eEF1A1 and eEF1A2
3 Difference in physical properties of eEF1A1 and eEF1A2
4 Principles of research
5 Common moonlighting functions of eEF1A1 and eEF1A2
6 Potential novel functions of the eEF1A1 isoform
7 Potential novel functions of eEF1A2 isoform
8 Concluding remarks
Acknowledgments
References
Chapter Four: Proteomics provides insights into the theranostic potential of extracellular vesicles
Abstract
1 Introduction
2 Advances in proteomics: Unveiling biological complexity, disease mechanisms, and personalized medicine
3 The protein cargoes of EVs are influenced by different factors
4 More studies are needed; Available databases
5 Conclusion
References
Chapter Five: Towards a structural and functional analysis of the immunoglobulin-fold proteome
Abstract
1 Introduction to the immunoglobulin fold
2 Ig fold proteome in physiology and disease
3 Applications of the Ig fold domains
Acknowledgments
References
Chapter Six: Functional unfoldomics: Roles of intrinsic disorder in protein (multi)functionality
Abstract
1 Most of the textbook knowledge about proteins is incomplete: introducing the protein intrinsic disorder phenomenon
2 Structural complexity of intrinsic disorder
3 Complexity of the disorder-based functional code and protein structure-function continuum
4 Major disorder-based biological functions
5 Interaction specialists: intrinsic disorder is advantageous for interactions
6 Disorder-based foldable binding sites of proteins: static disorder-based interactions
7 Fuzzy or dynamic complexes: binding with minimal folding or with no folding at all
8 Liquid-liquid phase separation, membrane-less organelles, and intrinsic disorder
9 Concluding remarks
References
Chapter Seven: Analysis of endoglucanases production using metatranscriptomics and proteomics approach
Abstract
1 Introduction
2 Application of endoglucanases
3 Metatranscriptomic approach
4 Proteomics tool for analyzing endoglucanase production
5 Conclusion
Acknowledgement
References
Chapter Eight: In silico network pharmacology study on Glycyrrhiza glabra: Analyzing the immune-boosting phytochemical properties of Siddha medicinal plant against COVID-19
Abstract
Abbreviations
1 Introduction
2 Materials and methods
3 Results
4 Discussion
5 Conclusion
References
Chapter Nine: In silico network pharmacology analysis and molecular docking validation of Swasa Kudori tablet for screening druggable phytoconstituents of asthma
Abstract
1 Introduction
2 Materials and methods
3 Results
4 Discussion
References
Chapter Ten: Proteomics and genomics insights on malignant osteosarcoma
Abstract
1 Introduction
2 Types of osteosarcoma
3 Bone metastasis
4 Etiology of osteosarcoma
5 Epidemiology of osteosarcoma
6 Epigenetic of osteosarcoma
7 Gene mutation
8 Molecular biology and pathogenesis of osteosarcoma
9 Pathway involved in osteosarcoma
10 Biomarker of osteosarcoma
11 Proteomics in osteosarcoma
12 Diagnosis and staging
13 Cancer treatment caused bone loss
14 Future perspective
References
Chapter Eleven: Application of functional proteomics in understanding RNA virus-mediated infection
Abstract
1 Introduction
2 Functional proteomics—overview
3 Methodologies of functional proteomics
4 Implementation of functional proteomics in RNA viral infection study
5 Therapeutic application and proteomics
6 Diagnosis
7 Detection
8 Conclusion and perspectives
References
Chapter Twelve: The biofilm proteome of Staphylococcus aureus and its implications for therapeutic interventions to biofilm-associated infections
Abstract
1 Introduction
2 Role of proteins in S. aureus biofilm formation
3 Regulation of biofilm phenotype in S. aureus
4 Anti-biofilm therapeutic interventions
5 Conclusion
References
Chapter Thirteen: A computational pipeline elucidating functions of conserved hypothetical Trypanosoma cruzi proteins based on public proteomic data
Abstract
1 Introduction
2 Results
3 Discussion
4 Conclusions
5 Material and methods
6 Uniform manifold approximation and projection (UMAP) and clusterization analysis
7 Gene ontology enriched terms
8 Three-dimensional structure generation and analysis
9 Conserved protein domain mapping

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