(Ebook PDF) Current Developments in Biotechnology and Bioengineering Human and Animal Health Applications 1st Edition by Vanete Thomaz Soccol 0444636714 9780444636713 full chapters

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ISBN-10 :  0444636714 

ISBN-13 :  9780444636713

Author : Vanete Thomaz Soccol 

Current Developments in Biotechnology and Bioengineering: Human and Animal Health Applications provides extensive coverage of new developments, state-of-the-art technologies, and potential future trends, presenting data-based scientific knowledge and information on medical biotechnological interventions for human and animal health.

Current Developments in Biotechnology and Bioengineering. Human and Animal Health Applications 1st Table of contents:

Part 1. Perspectives in Biotechnology Health
1. Biopharmaceutical Products: An Introduction
1.1. Introduction
1.2. The Biopharmaceutical Sector: Market Aspects
1.3. Types of Biopharmaceutical Products for Human Health
1.4. Production Processes for Recombinant Therapeutic Proteins
1.5. Technological Challenges and Future Perspectives
2. Biopharmaceuticals and Biosimilars
2.1. Introduction
2.2. Biopharmaceuticals: Classes, Variations, and Applications
2.3. Biosimilars
2.4. Heterologous Systems for Protein Expression
2.5. Financial Market
2.6. Legislation History and World Regulations
2.7. Perspectives: Pharmacogenomics and Next-Generation Biopharmaceuticals
Part 2. Immunotechnology
3. Interferons
3.1. Interferons: Biological Functions and Clinical Uses
3.2. Interferon Production and Formulation
3.3. Modified or New (Synthetic) Interferons and Formulation
4. Monoclonal Antibodies
4.1. Introduction to the Immune System
4.2. Monoclonal Antibody Development
4.3. Monoclonal Antibody Nomenclature
4.4. Monoclonal Antibodies in Research
4.5. Clinical Uses of Monoclonal Antibodies
4.6. Conclusion and Perspectives
5. Recombinant Antibodies: Trends for Standardized Immunological Probes and Drugs
5.1. Introduction
5.2. Natural Antibodies: Structure and Applications
5.3. Recombinant Antibodies: Wide Range of Alternative Antibody Fragments
5.4. Main Sources of Recombinant Antibodies
5.5. Recombinant Antibodies as Emerging Molecules for Pharmacologic Treatments
5.6. Recombinant Antibodies: New Tools for Research and Clinical Analysis
5.7. Producing Recombinant Antibodies
5.8. Conclusions and Perspectives
Part 3. Combinatorial Libraries
6. Impacts of Aptamer Technology on Diagnostics, Biotechnology, and Therapy
6.1. Systematic Evolution of Ligands by Exponential Enrichment Technique
6.2. Therapeutics Features of Aptamers
6.3. From Basic Research to Therapeutics: Application of Aptamers
6.4. Aptamers in Clinical Trials
6.5. Conclusions
7. Synthetic Peptide Libraries: Chemical Diversity to Reach Lead Compounds
7.1. Introduction
7.2. Preparation of Synthetic Peptide Libraries
7.3. Peptides as Drugs
7.4. Recent Applications
7.5. Conclusions and Perspectives
8. Biotechnological Role of Phage-Displayed Peptides for the Diagnosis of Neglected Tropical Diseases
8.1. Introduction
8.2. Hansen Disease: Example of Rarity of Antigens and Patients’ Antibodies
8.3. Antibody Purification Based on Affinity to Membrane-Blotted Antigens
8.4. Parasitic Infections: Elution Strategy of Phage-Displayed Peptides When Antigens Are Available
8.5. Phage Enzyme-Linked Immunosorbent Assay
8.6. Characterization of Peptide Sequences
8.7. Conclusion and Perspectives
Part 4. Gene and Cell Therapy
9. Systems and Synthetic Biology Applied to Health
9.1. Systems Biology: The Dawn of a Holistic Vision in Biomedicine
9.2. Approaches to Systems Biology
9.3. The Network: A New, Powerful Paradigm in Biology
9.4. Network Measures for Biological Systems
9.5. Types of Biological Networks
9.6. Networks Studies Applied to Understand Key Molecules and Disease Processes
9.7. Rheumatoid Arthritis
9.8. The Nuclear Factor-κB Pathway Interactome
9.9. Introduction to Mathematical Modeling
9.10. From Classical Modeling to Microscopic Simulations
9.11. Microscopic Simulation of the Immune System
9.12. Basic Aspects of Synthetic Biology
9.13. Synthetic Biology and Disease Diagnosis
9.14. Synthetic Biology and Disease Therapy
9.15. Synthetic Biology and Disease Prevention
9.16. Biosafety and Ethical Aspects Surrounding Synthetic Biology
9.17. Conclusion and Future Perspectives
10. Noncoding RNAs as Critical Players in Regulatory Accuracy, Redox Signaling, and Immune Cell Functions
10.1. Noncoding RNA Molecules: From Evolution to Human Disease Therapy
10.2. Biogenesis Pathways of Noncoding RNAs: An Overview
10.3. MicroRNAs: Key Posttranscriptional Regulators of Gene Expression
10.4. Long Noncoding RNAs: How Far Are Their Strategies to Regulate Gene Expression?
10.5. Final Considerations
Part 5. Tissue Engineering
11. Implications of Substrate Topographic Surface on Tissue Engineering
11.1. Biomimetic Constructs for Tissue Engineering
11.2. How Scaffold Is Structurally Organized
11.3. Effects of Scaffold Physical Structure on Cell Behavior
11.4. Conclusions and Perspectives
12. Tissue Engineering: The Use of Stem Cells in Regenerative Medicine
12.1. Introduction
12.2. Stem Cell Isolation and Differentiation
12.3. Cells Maintenance and Characterization
12.4. Conclusions and Perspectives
13. Tissue Engineering and Regenerative Medicine Solutions for the Abdominal Organs
13.1. Introduction
13.2. Cell Types in Organ Bioengineering
13.3. Gastrointestinal Tract
13.4. Bladder
13.5. Kidney
13.6. Pancreas
13.7. Liver
13.8. The Challenge of Immunosuppression
13.9. Conclusions and Perspectives
Abbreviations
14. Mesenchymal Stem Cells Seeded on Biofunctionalized Scaffold for Tissue Engineering
14.1. Introduction
14.2. Pluripotency of Stem Cells
14.3. Substrate
14.4. Biomaterials
14.5. Scaffold Interaction With Mesenchymal Stem Cells
14.6. Conclusions
Part 6. Biofilms and Biosurfactants in Health
15. Biosurfactants as Antimicrobial and Antibiofilm Agents
15.1. Introduction
15.2. Biofilms
15.3. Current Approaches to Preventing or Removing Biofilms
15.4. Surface Active-compounds as Potential Antibiofilm Agents
15.5. Potential Use of Biosurfactants in Nanotechnology
15.6. Conclusion and Perspectives
16. Bacteriocins as Antimicrobial and Antibiofilm Agents
16.1. Introduction
16.2. Classification
16.3. Mechanisms of Action
16.4. Antimicrobial and Antibiofilm Activities of Bacteriocins
16.5. Antimicrobial and Antibiofilm Investigations With Liposome-Entrapped Bacteriocins
16.6. Conclusion and Perspectives
Part 7. Vaccines and Vaccinology
17. Recombinant Veterinary Vaccines
17.1. Introduction
17.2. Types of Recombinant Vaccines
17.3. Immune Responses Induced by Vaccination
17.4. Veterinary Vaccine Production
17.5. Recombinant Vaccines Against Bacterial and Fungal Diseases
17.6. Recombinant Vaccines Against Parasitic Diseases
17.7. Recombinant Vaccines Against Viral Diseases
17.8. Conclusions and Perspectives
18. Development of Process to Produce Recombinant Component for Acellular Pertussis Vaccine
18.1. Introduction
18.2. Technological Development: Case Description
18.3. Conclusions
19. Cloning and Expression of a Heterologous Protein With Imunological Potential Against Corynebacterium diphtheriae
19.1. Introduction
19.2. Historical Aspects
19.3. The Pathogen and the Toxin
19.4. The Disease
19.5. Epidemiology
19.6. Diphtheria Vaccines
19.7. Technological Development of a Diphtheria Vaccine: Case Description
19.8. Conclusions and Perspectives
20. Veterinary Rabies Vaccine
20.1. Introduction
20.2. Case Study
20.3. Conclusion and Perspectives
List of Abbreviations
21. Development of a Rabies Vaccine in Cell Culture for Veterinary Use in the Lyophilized Form
21.1. Rabies Virus and Rabies Vaccines
21.2. Freeze-Drying: Process and Use in Vaccines
21.3. Case Study
21.4. Perspectives
Part 8. Biotechnology Applied to Parasites
22. Antileishmanial Biocompound Screening
22.1. Introduction
22.2. Primary Chemotherapy With Antimonials
22.3. Second Generation of Antileishmanial Drugs
22.4. Antileishmanial Drug Development Review
22.5. Biotechnological Development of New Antileishmanial Drugs
22.6. Methods for Anti-Leishmania Drug Screening
22.7. Conclusions and Perspectives
Part 9. Biotechnology of Reproduction
23. Factors/Genes in Maternal Recognition of Pregnancy: An Overview
23.1. Introduction
23.2. Maternal Recognition of Pregnancy
23.3. Gene Regulating Maternal Recognition of Pregnancy Events
23.4. Causes of Early Embryo Loss
23.5. Strategies for Reducing Early Embryonic Wastage
23.6. Conclusion

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