Cyclized Helical Peptides: Synthesis, Properties, and Therapeutic Applications

Cyclized Helical Peptides: Synthesis, Properties, and Therapeutic Applications – Ebook Instant Download/Delivery ISBN(s): 9783527343423,3527343423

Product details:

• ISBN 13:9783527343454
• Author: Zigang Li,Hui Zhao , Chuan Wan 

Constraint helical peptides have emerged as a solution to target previously undruggable protein-protein interactions, which feature large and complex surfaces. Cyclized Helical Peptides: Synthesis, Properties and Therapeutic Applications offers a review of the most current methodologies of constructing constrained helices. The authors noted experts on the topic include the information on the fundamental features of cyclized helical peptides and discuss their limitations. The book summarizes and explores the effects of chemical methods constructing helical peptides on helicity, binding affinity, cell penetration, and nonspecific toxicity.

The book examines the therapeutic applications of the constraint helices and includes comparison with existing small molecule modulators or antibodies. Designed as a useful resource for both those outside and inside the field. Those new to the field will find a comprehensive introduction to cyclized helical peptide and those inside the field will find a deeper understanding of the topic.

Table contents:

1 Introduction
2 Construction of Constrained Helices
3 Properties of Stabilized Peptides
4 Applications of Constrained Helices
5 Stabilized Peptide Covalent Inhibitors
6 Stabilized Peptide PROTAC
7 Stabilized Peptide for Drug Delivery
8 Outlook

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