Detection of Drugs and Their Metabolites in Oral Fluid Emerging Issues in Analytical Chemistry 1st Edition by Robert White, Christine Moore 0128145968 9780128145968

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Product details:

ISBN-10 :  0128145968 

ISBN-13 :  9780128145968

Author :  Robert M. White, Christine M. Moore 

Detection of Drugs and Their Metabolites in Oral Fluid presents the analytical chemistry methods used for the detection and quantification of drugs and their metabolites in human oral fluid. The authors summarize the state of the science, including its strengths, weaknesses, unmet methodological needs, and cutting-edge trends. This volume covers the salient aspects of oral fluid drug testing, including specimen collection and handling, initial testing, point of collection testing (POCT), specimen validity testing (SVT), and confirmatory and proficiency testing. Analytes discussed include amphetamines, cannabinoids, cocaine, opiates, phencyclidine, cannabimimetics, and miscellaneous drugs.

Detection of Drugs and Their Metabolites in Oral Fluid (Emerging Issues in Analytical Chemistry) 1st Table of contents:

Chapter 1. Introduction
Abstract
General
Disease States That May Influence Salivary Function
The Influence of Drugs on Salivary Function
References
Chapter 2. Oral Fluid Pharmacokinetics
Abstract
Introduction
Ethanol
Cannabinoids
Cocaine
Amphetamines
Opiates
Benzodiazepines
Other Drugs
New Psychoactive Substances
References
Chapter 3. Collection of Oral Fluid
Abstract
Introduction
Neat Oral Fluid
Saliva Collection System
Pad, No Buffer
Pad and Buffer
Summary
References
Chapter 4. Point of Collection Testing
Abstract
Introduction
Evaluation
Specific Applications
References
Chapter 5. Initial Testing
Abstract
Introduction
Sensitivity
Cross-Reactivity
Chromatography–Mass Spectrometry
Conclusions
References
Chapter 6. Specimen Validity Testing
Abstract
Introduction
Oral Fluid SVT
Conclusion
References
Chapter 7. Confirmatory Testing
Abstract
Introduction
Separation
Method Validation
Sensitivity
Major Drug Classes
Novel Psychoactive Substances
Derivatization in LC-MS
Summary
References
Chapter 8. Interlaboratory Comparison
Abstract
Introduction
Commercial Controls
Blind Controls
Proficiency Testing
Performance Testing
Summary
References
Chapter 9. Individual Analytes, Specimen Handling, Stability, and Other Issues
Abstract
Introduction
Oral Fluid
Δ9-Tetrahydrocannabinol
Cocaine
Amphetamines
Opiates
Benzodiazepines
References
Chapter 10. Concluding Remarks
Abstract
Strengths of Oral Fluid as a Test Matrix
Weaknesses of Oral Fluid as a Test Matrix
Methodological Needs
Cutting-Edge Trends

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Tags: Detection, Their Metabolites, Oral Fluid, Analytical Chemistry, Robert White, Christine Moore