Epigenetics and DNA Damage 1st edition by Miriam Galvonas Jasiulionis 0323910823 9780323910828

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Product details:

ISBN-10 :  0323910823 

ISBN-13 :  9780323910828

Author :  Miriam Galvonas Jasiulionis 

Although scientists recognize the role of epigenetic mechanisms in DNA damage response, the complex, mechanistic interplay between chromatin regulation and DNA repair is still poorly understood. Comprehending how these processes are connected in time and space and play out in developmental processes may reveal novel directions for new research and disease treatment.

Epigenetics and DNA Damage, a new volume in the Translational Epigenetics series, offers a thorough grounding in the relationship between DNA Damage, epigenetic modifications, and chromatin regulation. Early chapters address the basic science of DNA damage and its association with various epigenetic mechanisms, including DNA methylation, post-translational histone modifications, histone variants, chromatin remodeling, miRNAs, and lncRNAs. This is followed by a close discussion of DNA damage and epigenetics in metabolism, aging, cellular differentiation, immune function, stem cell biology, and cancer, tying recent research to translational application in disease understanding. Later chapters examine possible epigenetic therapies combining DNA damage induction and epigenetic alteration, as well as instructive chapters on how to analyze DNA damage and epigenetic alterations in new research.

 

Epigenetics and DNA Damage 1st Table of contents:

Section 1: Understanding the relationship between DNA damage and epigenetic mechanisms
Chapter 1: DNA damage and DNA methylation
Abstract
Introduction
Base modifications
DNA methylation and DNA damageability
Dynamics of DNA methylation
DNA repair factors and DNA methylation
DNA methylation upon DNA repair
References
Chapter 2: DNA damage and histone modifications
Abstract
Introduction
Histone modifications in DNA double-stranded break repair
Histone modifications in DNA excision repair
Histone modifications in DNA mismatch repair
Concluding remarks
References
Chapter 3: DNA damage and histone variants
Abstract
Introduction
DDR mechanisms
Histone variants
Role of histone variants in DDR
Conclusions
References
Chapter 4: DNA damage and miRNAs
Abstract
MicroRNA biogenesis and maturation
Effects of DDR on miRNA biogenesis
miRNAs and double-strand break (DSB) repair
miRNAs and homologous recombination (HR) repair
miRNAs and nonhomologous end-joining (NHEJ) repair
miRNAs and base excision repair (BER)
miRNAs and nucleotide excision repair (NER)
miRNAs DNA mismatch repair (MMR)
Role of miRNAs in cell cycle arrest and apoptosis
DDR, miRNAs, and cancer development and treatment
References
Chapter 5: DNA damage and lncRNAs
Abstract
Introduction
lncRNAs and their biogenesis
lncRNAs in other signaling pathways
lncRNAs and DNA repair
The role of lncRNAs in the DDR regulation
Conclusion
References
Chapter 6: DNA damage, sirtuins, and epigenetic marks
Abstract
Sirtuins
Sirtuins and chromatin remodeling
Sirtuins and epigenetic modifications
Sirtuins and telomere maintenance
Sirtuins and genomic stability
Sirtuins and diseases
Concluding remarks
References
Section 2: DNA damage and epigenetics—Their impact in the onset of diseases
Chapter 7: DNA damage, metabolism, and epigenetic regulation
Abstract
Acknowledgments
Introduction
Crosstalk between epigenetics and metabolism in cancer
Metabolic dysfunction, epigenetic modification, and genomic instability
Epigenetics and steroid hormone metabolism in endocrine-driven cancer
Conclusions and perspectives
References
Chapter 8: DNA damage, epigenetics, and aging
Abstract
Introduction
Epigenetic modifications versus DNA damage
DNA damage causes cellular senescence and aging
Epigenetic marks that prevent DNA damage and aging: Youth-associated genome-stabilizing epigenetic marks
How epigenetic modifications prevent DNA damage and the aging process: DNA Protection vs. DNA repair
IRS hypomethylation drives the molecular pathogenesis of age-related noncommunicable diseases
Youth-DNA-GAPs
The fountain of youth
References
Chapter 9: DNA damage signaling, cell reprogramming, and differentiation
Abstract
Introduction
DNA damage signaling in cell reprogramming and differentiation
iPS cells derived from DNA repair-deficient disease
NHEJ factors (DNA-PKcs, LIG IV, and Artemis)
Conclusion
References
Chapter 10: The interplay between DNA damage and epigenetics in cancer
Abstract
Introduction
Genetic factors
Environmental exposures
The cancer epigenome and DNA damage
Susceptibility of the cancer epigenome to DNA damage
Targeting DNA damage and epigenetic changes in cancer diagnosis and treatment
Conclusion
References
Chapter 11: Oncometabolites, epigenetic marks, and DNA repair
Abstract
Oncometabolite biology
Oncometabolites and DNA repair
References
Section 3: Therapeutic strategies inducing DNA damage and epigenetic alterations
Chapter 12: Cancer therapies inducing DNA damage
Abstract
Acknowledgments
Introduction
Mechanisms of DNA damage by radiotherapy
DNA damage-inducing chemotherapies
Conclusions
References
Chapter 13: Epigenetic therapy and DNA damage response
Abstract
Introduction
Commonly altered epigenetic regulatory proteins implicated in cancer and their implication for therapy
Targeting the epigenetics of the DNA damage response in cancer: The concept of synthetic lethality
Conclusion: Implications of epigenetic regulation for improved cancer treatment
References
Section 4: Experimental approaches to study DNA damage and epigenetic modifications
Chapter 14: Useful protocols to study DNA damage
Abstract
Acknowledgments
Introduction
Alkaline comet assay
DNA lesions immunodetection
Final remarks
References
Chapter 15: Useful methods to study epigenetic marks: DNA methylation, histone modifications, chr

 

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