Hematopathology 2nd Edition by Elaine Sarkin Jaffe 032338871X 9780323388719

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ISBN-10 :  032338871X 

ISBN-13 : 9780323388719

Author : Elaine Sarkin Jaffe 

The world’s leading reference in hematopathology returns with this completely updated second edition. Authored by international experts in the field, it covers a broad range of hematologic disorders — both benign and malignant — with information on the pathogenesis, clinical and pathologic diagnosis, and treatment for each. Comprehensive in scope, it’s a must-have resource for both residents and practicing pathologists alike.

Hematopathology 2nd Table of contents:

Part I Technical Aspects
Chapter 1 Processing of the Lymph Node Biopsy Specimen
Instructions for the Surgeon
Gross Processing of the Lymph Node Biopsy by the Pathologist
Routine Histologic, Histochemical, and Special Stains
Choice of Ancillary Studies
Reporting the Lymph Node Biopsy
Pearls and Pitfalls
References
Chapter 2 Fine Needle Aspiration of Lymph Nodes
Specimen Collection and Processing
Ancillary Studies
Non-Neoplastic Aspirates
Aspirates of Lymphoid Neoplasms
Limitations of Fine Needle Aspiration
Role of Core Needle Biopsy in Lymphoma Diagnosis
References
Chapter 3 Collection, Processing, and Examination of Bone Marrow Specimens
Medical Indications for Bone Marrow Examination
Components of a Bone Marrow Evaluation
Collection of Bone Marrow Aspirate and Core Biopsy
Processing of Marrow Trephine Biopsy and Aspirate
Bone Marrow Examination
Final Report
Conclusion
Acknowledgments
Pearls and Pitfalls
References
Chapter 4 Immunohistochemistry for the Hematopathology Laboratory
Basic Immunohistochemistry
Antigens of Hematopathologic Interest
Beyond Diagnostics: The Evolving Role of Immunohistochemistry
In Situ Hybridization
Conclusion
Pearls and Pitfalls
References
Chapter 5 Flow Cytometry
General Principles
Technical Considerations
Flow Cytometry in Diagnosis and Classification of Mature B-Cell Neoplasms
Plasma Cell Disorders
Flow Cytometry in Diagnosis and Classification of Mature T-Cell Neoplasms
Flow Cytometry in Diagnosis and Classification of Natural Killer Cell Neoplasms
Flow Cytometry in Diagnosis and Classification of Acute Leukemia
Flow Cytometry and the Diagnosis of Myelodysplastic Syndromes and Myeloproliferative Neoplasms
Acknowledgments
Pearls and Pitfalls
References
Chapter 6 Molecular Diagnosis in Hematopathology
Nucleic Acid Isolation and Tumor Enrichment
Antigen Receptor Gene Rearrangements
Major Molecular Methodologies
Lymphoid Neoplasms
Myeloid Neoplasms
Potential Pitfalls of Molecular Testing
Summary and Conclusions
Pearls and Pitfalls
References
Chapter 7 Important Chromosomal Aberrations in Hematologic Neoplasms and Key Techniques to Diagnose Them
Types of Chromosomal Aberrations in Hematologic Malignancies
Conventional Cytogenetic Methods
Molecular Cytogenetic Methods
Clinical Relevance of Chromosomal Abnormalities in Hematologic Malignancies
Conclusion
Pearls and Pitfalls
Acknowledgments
References
Part II Normal and Reactive Conditions of Hematopoietic Tissues
Chapter 8 Normal Lymphoid Organs and Tissues
Normal Lymphoid Tissues
B-Cell and T-Cell Differentiation
Pearls and Pitfalls
References
Chapter 9 Reactive Lymphadenopathies
Follicular and Nodular Patterns
Predominantly Sinus Pattern
Interfollicular or Mixed Patterns
Diffuse Pattern
Pearls and Pitfalls
References
Chapter 10 Normal Bone Marrow
Hematopoiesis
Bone Marrow Lymphoid Cells
Other Cells Present in Normal Bone Marrow
Cytochemistry and Histochemistry
Conclusion
Pearls and Pitfalls
References
Chapter 11 Evaluation of Anemia, Leukopenia, and Thrombocytopenia
Evaluation of Anemia
Evaluation of Leukopenia
Evaluation of Thrombocytopenia
Evaluation of Specific Bone Marrow Failure Syndromes
References
Chapter 12 Bone Marrow Findings in Inflammatory, Infectious, and Metabolic Disorders
Reactive Neutrophilia
Reactive Lymphocytosis
Reactive Eosinophilia
Reactive Basophilia
Reactive Monocytosis
Bone Marrow in Infectious Disorders
Bone Marrow in Non-infectious Systemic and Inflammatory Disorders
Conclusion
References
Part III Lymphoid Neoplasms
Chapter 13 Principles of Classification of Lymphoid Neoplasms
Historical Background
Early Events in Lymphoid Neoplasia: Borderlands of Malignancy
Small B-Cell Neoplasms
Aggressive B-Cell Lymphomas and Borderline Malignancies
Peripheral T-Cell Lymphomas
Histiocytic and Dendritic Cell Neoplasms
Conclusion
Pearls and Pitfalls
References
Section 1 Mature B-Cell Neoplasms
Chapter 14 B-Cell Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma, Monoclonal B-Cell Lymphocytosis, and B-Cell Prolymphocytic Leukemia
B-Cell Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (B-CLL/SLL)
Monoclonal B-Cell Lymphocytosis (MBL)
B-Prolymphocytic Leukemia
Pearls and Pitfalls
References
Chapter 15 Lymphoplasmacytic Lymphoma and Waldenström Macroglobulinemia
Definition of Disease
Epidemiology and Incidence
Clinical Features
Morphology
Immunophenotype
Genetic Features
Postulated Normal Counterpart and Pathogenesis
Clinical Course, Treatment, and Prognosis
Differential Diagnosis
Pearls and Pitfalls
References
Chapter 16 Hairy Cell Leukemia
Definition of Disease and Nomenclature
Epidemiology
Etiology
Clinical Features
Morphology
Phenotype
Genetics and Molecular Findings
Postulated Cell of Origin and Normal Counterpart
Variants
Differential Diagnosis
Clinical Course and Treatment
Prognostic and Predictive Factors
Pearls and Pitfalls
References
Chapter 17 Splenic Marginal-Zone Lymphoma and Other Small B-Cell Neoplasms in the Spleen
Definition
Epidemiology
Etiology
Clinical Features
Morphology
Immunophenotype
Genetics
Other Splenic B-Cell Lymphomas
Pearls and Pitfalls
References
Chapter 18 Follicular Lymphoma
Definition
Epidemiology
Clinical Features
Morphologic Features
Immunophenotype
Cytogenetic and Genetic Features
Postulated Normal Counterpart and Pathogenesis
Etiology
Clinical Course
Variants
Other Lymphomas with Follicular Pattern
Differential Diagnosis
Conclusion
Pearls and Pitfalls
References
Chapter 19 Extranodal Marginal Zone Lymphoma
Histology of the Mucosal Immune System
Peyer’s Patches
Definition of Malt Lymphoma
Epidemiology
Etiology
Histopathology of Acquired Malt
Pathology of Malt Lymphoma
Immunohistochemistry
Genetic Features of Malt Lymphoma
Postulated Cell of Origin
Clinical Course
Differential Diagnosis
Pearls and Pitfalls
References
Chapter 20 Primary Cutaneous B-Cell Lymphomas
Classification
Primary Cutaneous Marginal-Zone Lymphoma
Primary Cutaneous Follicle-Center Lymphoma
Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type
Intravascular Large B-Cell Lymphoma
B-Lymphoblastic Lymphoma
Cutaneous Immunodeficiency-Associated Lymphproliferative Disorders
Pearls and Pitfalls
References
Chapter 21 Nodal Marginal Zone Lymphoma
Definition
Epidemiology, Etiology, and Cofactors
Clinical Features
Morphology
Immunophenotype
Genetics and Molecular Findings
Postulated Cell of Origin
Clinical Course and Prognostic Factors
Pediatric Nodal Marginal Zone Lymphoma
Differential Diagnosis
Pearls and Pitfalls
References
Chapter 22 Mantle Cell Lymphoma
Definition
Epidemiology and Clinical Manifestations
Postulated Cell of Origin
Morphology
Immunophenotype
Cytogenetic Findings
Molecular Characteristics
Multistep Development and in Situ Mantle Cell Neoplasia
Mantle Cell Lymphoma Variants
Clinical Course
Prognostic Parameters
Therapy
Differential Diagnosis
Pearls and Pitfalls
References
Chapter 23 Diffuse Large B-Cell Lymphoma
Definition
Epidemiology
Etiology
Clinical Features
Morphology
Immunophenotype
Genetics
Molecular Subtypes: Germinal-Center B-Cell Type and Activated B-Cell Type
Postulated Cell of Origin
Clinical Course
Prognostic Factors
Differential Diagnosis
Other Lymphomas of Large B-Cells
Pearls and Pitfalls
References
Chapter 24 Burkitt’s Lymphoma and Its Mimics
Burkitt’s Lymphoma
High-Grade B-Cell Lymphomas Other Than Burkitt’s Lymphoma and Diffuse Large B-Cell Lymphoma
Other Differential Diagnoses of Burkitt’s Lymphoma
A Practical Approach to the Diagnosis of Burkitt’s Lymphoma
Pearls and Pitfalls
References
Chapter 25 Plasmablastic Neoplasms Other Than Plasma Cell Myeloma
Plasmablastic Lymphoma
ALK-Positive Large B-Cell Lymphoma
Pearls and Pitfalls
References
Chapter 26 Plasma Cell Neoplasms
Plasma Cell Neoplasms
Plasma Cell Myeloma (Multiple Myeloma)
Monoclonal Gammopathy of Undetermined Significance
Plasmacytoma
Immunoglobulin Deposition Diseases
Plasma Cell Neoplasms With Associated Paraneoplastic Syndrome
Pearls and Pitfalls
References
Chapter 27 Nodular Lymphocyte–Predominant Hodgkin’s Lymphoma
Definition
Historical Background
Epidemiology
Clinical Features
Morphology
Immunophenotype
Genetics and Molecular Findings
Relation to Progressively Transformed Germinal Centers
Transformation to Diffuse Large B-Cell Lymphoma
Relation to T-Cell/Histiocyte–Rich Large B-Cell Lymphoma
Other Differential Diagnoses
Treatment
Prognosis
Conclusion
Pearls and Pitfalls
References
Chapter 28 Classical Hodgkin’s Lymphoma and Related Lesions
Definition
Classification
Epidemiology
Etiology: Epstein-Barr Virus
Clinical Features
Morphology
Immunophenotype
Genetics and Molecular Findings
Postulated Cell of Origin
Clinical Course and Prognostic Markers
Related Lesions and Differential Diagnosis
Pearls and Pitfalls
References
Chapter 29 Virally Associated B-Cell Lymphoproliferative Disease
Chronic Active Epstein-Barr Virus of B-Cell Type
Epstein-Barr Virus–Positive Diffuse Large B-Cell Lymphoma
Epstein-Barr Virus Mucocutaneous Ulcer
Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation
Lymphomatoid Granulomatosis
KSHV/HHV-8-Associated Lymphoproliferative Disorders
References
Section 2 Mature T-Cell and NK-Cell Neoplasms
Chapter 30 Virally Associated T-Cell and NK-Cell Neoplasms
Epstein-Barr Virus–Associated Hemophagocytic Lymphohistiocytosis
Chronic Active Epstein-Barr Virus Infection of T-Cell or NK-Cell Type, Systemic
Severe Mosquito Bite Allergy
Hydroa Vacciniforme–Like Lymphoproliferative Disease
Systemic Epstein-Barr Virus–Positive T-Cell Lymphoma
Extranodal NK/T-Cell Lymphoma, Nasal-Type
Extranasal NK/T-Cell Lymphoma
Aggressive NK-Cell Leukemia
Epstein-Barr Virus–Positive Nodal NK/T-Cell Lymphoma
Pearls and Pitfalls
References
Chapter 31 T-Cell and NK-Cell Large Granular Lymphocyte Proliferations
History and Classification
Definition
Etiology and Epidemiology
Clinical Features
Morphology and Laboratory Studies
Genetics and Molecular Findings
Clinical Management and Prognosis
Differential Diagnosis
Pearls and Pitfalls
References
Chapter 32 T-Cell Prolymphocytic Leukemia
Definition
Epidemiology
Clinical Features
Morphology
Immunophenotype
Genetics and Molecular Findings
Postulated Cell of Origin
Clinical Course
Treatment
Differential Diagnosis
Pearls and Pitfalls
References
Chapter 33 Adult T-Cell Leukemia/Lymphoma
Definition
Epidemiology
Clinical Features
Morphology
Immunophenotype
Genetics, Molecular Findings, and Role of HTLV-1
Postulated Normal Counterpart
Clinical Course
Differential Diagnosis
Pearls and Pitfalls
References
Chapter 34 Hepatosplenic T-Cell Lymphoma
Definition
Epidemiology
Etiology
Clinical Features
Morphology
Immunophenotype
Genetics and Molecular Findings
Postulated Cell of Origin
Clinical Course
Differential Diagnosis
References
Chapter 35 Peripheral T-Cell Lymphoma, Not Otherwise Specified
Definition
Epidemiology
Clinical Features
Morphology
Variants
Immunophenotype
Genetics
Prognosis and Predictive Features
Differential Diagnoses
Pearls and Pitfalls
References
Chapter 36 Angioimmunoblastic T-Cell Lymphoma
Definition
Epidemiology
Etiology
Follicular Helper T Cells
Clinical Features
Morphology
Histological Variants and Related Lesions
Immunophenotype
Genetics
Clinical Course and Prognosis
Differential Diagnosis
Pearls and Pitfalls
References
Chapter 37 Anaplastic Large Cell Lymphoma, ALK Positive and ALK Negative
Definition and Background
Anaplastic Large Cell Lymphoma, ALK Positive
Anaplastic Large Cell Lymphoma, ALK Negative
Breast Implant–Associated Anaplastic Large Cell Lymphoma
Differential Diagnosis of Anaplastic Large Cell Lymphoma
Pearls and Pitfalls
References
Chapter 38 Enteropathy-Associated T-Cell Lymphoma and Other Primary Intestinal T-Cell Lymphomas
Enteropathy-Associated T-Cell Lymphoma (Type I, Classical)
Refractory Celiac Disease
Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma
Intestinal T-Cell Lymphoma, Not Otherwise Specified
Indolent NK-Cell and T-Cell Lymphoproliferative Disorders of the Gastrointestinal Tract
Pearls and Pitfalls
References
Chapter 39 Mycosis Fungoides and Sézary Syndrome
Mycosis Fungoides
Sézary Syndrome
Pearls and Pitfalls
References
Chapter 40 Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders
Definition
Epidemiology
Etiology
Clinical Features
Morphology
Immunophenotype
Genetics and Molecular Findings
Postulated Cell of Origin
Clinical Course
Differential Diagnosis
Other Skin Conditions with CD30-Positive Large Cells
Pearls and Pitfalls
References
Chapter 41 Primary Cutaneous T-Cell Lymphomas
Primary Cutaneous Aggressive Epidermotropic CD8+ Cytotoxic T-Cell Lymphoma
Primary Cutaneous γδ T-Cell Lymphoma
Subcutaneous Panniculitis-Like T-Cell Lymphoma
Cutaneous CD4+ Small/Medium T-Cell Lymphoproliferative Disorder
Other Types of Cutaneous T-Cell Lymphoma
Pearls and Pitfalls
References
Section 3 Precursor B- and T-Cell Neoplasms
Chapter 42 Precursor B- and T-Cell Neoplasms
Classification of Precursor Lymphoid Neoplasms
B-Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma
T-Cell Lymphoblastic Lymphoma/Lymphoblastic Leukemia
Conclusion
Pearls and Pitfalls
References
Chapter 43 Acute Leukemias of Ambiguous Lineage
Definition
Epidemiology and Etiology
Clinical Features
Acute Undifferentiated Leukemia
Mixed-Phenotype Acute Leukemia
Other Ambiguous Lineage Leukemias
Conclusion
Pearls and Pitfalls
References
Part IV Myeloid Neoplasms
Chapter 44 Principles of Classification of Myeloid Neoplasms
Evaluation of Myeloid Neoplasms
World Health Organization Classification
Conclusion
Acknowledgment
References
Chapter 45 Myelodysplastic Syndromes
Incidence
Clinical Features
Laboratory Features
Diagnosis
Classification
Differential Diagnosis
Causative Agents
Pathogenesis
Conclusion
Pearls and Pitfalls
References
Chapter 46 Acute Myeloid Leukemia
Epidemiology
Etiology
Clinical Features
Morphology
Cytochemistry
Immunophenotype
Genetics
Prognosis
Acute Myeloid Leukemia With Recurrent Genetic Abnormalities
Acute Myeloid Leukemia With Gene Mutations
Acute Myeloid Leukemia With Myelodysplasia-Related Changes
Therapy-Related Myeloid Neoplasms
Acute Myeloid Leukemia, Not Otherwise Specified
Myeloid Proliferations of Down’s Syndrome
Myeloid Sarcoma
Integrated Approach to the Diagnosis of Acute Myeloid Leukemia
Pearls and Pitfalls
References
Chapter 47 Myeloproliferative Neoplasms
Definition
Etiology and Pathogenesis
Chronic Myeloid Leukemia, BCR-ABL1 Positive
Chronic Neutrophilic Leukemia
Polycythemia Vera
Primary Myelofibrosis
Essential Thrombocythemia
Myeloproliferative Neoplasms, Unclassifiable
Pearls and Pitfalls
References
Chapter 48 Myelodysplastic/Myeloproliferative Neoplasms
Etiology and Pathogenesis
Chronic Myelomonocytic Leukemia
Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative
Myelodysplastic/Myeloproliferative Neoplasm With Ring Sideroblasts and Thrombocytosis
Juvenile Myelomonocytic Leukemia
Myelodysplastic/Myeloproliferative Neoplasm, Unclassifiable
Pearls and Pitfalls
References
Chapter 49 Mastocytosis
Definition
General Aspects
Epidemiology and Etiology
Postulated Cell of Origin and Normal Counterpart
Genetics and Molecular Findings
Cytologic and Histologic Diagnosis
Differential Diagnosis
Classification
Pearls and Pitfalls
Acknowledgment
References
Chapter 50 Eosinophilia and Chronic Eosinophilic Leukemia, Including Myeloid/Lymphoid Neoplasms with Eosinophilia and Rearrangement of PDGFRA, PDGFRB, FGFR1, or JAK2
Evaluation of Eosinophilia
Causes of Eosinophilia
Conclusion
Pearls and Pitfalls
References
Chapter 51 Blastic Plasmacytoid Dendritic Cell Neoplasm
Definition
Epidemiology
Etiology
Clinical Features
Morphology
Immunophenotype
Cytochemistry
Genetics and Molecular Findings
Postulated Cell of Origin and Normal Counterpart
Clinical Course and Prognosis
Differential Diagnosis
Pearls and Pitfalls
References
Part V Histiocytic Proliferations
Chapter 52 Non-neoplastic Histiocytic Proliferations of Lymph Nodes and Bone Marrow
Sinus Histiocytosis with Massive Lymphadenopathy (Rosai-Dorfman Disease)
Hemophagocytic Syndromes
Niemann-Pick Disease
Gaucher’s Disease
Tangier Disease
Pearls and Pitfalls
References
Chapter 53 Histiocytic and Dendritic Cell Neoplasms Including Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma
The Histiocytes
Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma
Other Histiocytic and Dendritic Cell Neoplasms
Erdheim-Chester Disease
Conclusion
Pearls and Pitfalls
References
Part VI Immunodeficiency Disorders
Chapter 54 The Pathology of Primary Immunodeficiencies
Classification
Epidemiology
Severe Combined Immunodeficiency
PI3K-Related Immunodeficiencies
Defects That Affect Homeostasis of the Immune System
Defects in Synapse Formation and Crosstalk between Antigen-Presenting Cells and T-Cells
Pearls and Pitfalls
References
Chapter 55 Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders
Definition
Post-Transplant Lymphoproliferative Disorders
Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders in Non-transplant Settings
Pearls and Pitfalls
References
Part VII Site-Specific Issues in the Diagnosis of Lymphoma and Leukemia
Chapter 56 Bone Marrow Evaluation for Lymphoma
Distinction between Benign Lymphoid Aggregates and Lymphoma
Non-Hodgkin’s Lymphoma Involving Bone Marrow
Characteristic Features of B-Cell Lymphomas Involving Bone Marrow
Characteristic Features of T-Cell Lymphomas Involving Bone Marrow
Characteristic Features of Hodgkin’s Lymphoma Involving Bone Marrow
Non-lymphoid Malignant Neoplasms That Mimic Lymphomas
Pearls and Pitfalls
References
Chapter 57 Evaluation of the Bone Marrow After Therapy
General Approach
Acute Leukemia or Myelodysplastic Syndrome
BCR-ABL1–Positive Chronic Myeloid Leukemia
BCR-ABL1–Negative Myeloproliferative Neoplasms
Chronic Lymphoproliferative and Plasma Cell Disorders
Other Bone Marrow Changes After Therapy
References
Chapter 58 Non-hematopoietic Neoplasms of the Bone Marrow
Definition
Invasive Breast Carcinoma
Carcinoma of the Lung
Squamous Cell Carcinoma
Adenocarcinomas
Metastatic Prostate Cancer
Carcinomas of the Stomach
Colorectal Carcinomas
Renal Cell Carcinoma
Malignant Melanoma
Pediatric Cancers
Neuroectodermal Tumor of Bone
Cartilage-Forming Tumors
Hemangiomas
Epithelioid Hemangioendotheliomas
Other Soft Tissue Tumors
Malignant Lymphomas
Benign Tumor-Like Lesions of the Bone
Metaphyseal Fibrous Defect (Non-Ossifying Fibroma)
Paget’s Disease
Chronic Osteomyelitis
Conclusion
Pearls and Pitfalls
References
Chapter 59 Non-lymphoid Lesions of the Lymph Nodes
Metastatic Tumors in Lymph Nodes
Benign Lymph Node Inclusions
Mesenchymal Proliferations in Lymph Nodes
Pearls and Pitfalls
References
Chapter 60 Spleen
The Normal Spleen
Gross Examination
Lymphoid Hyperplasia
Castleman’s Disease
Autoimmune Lymphoproliferative Syndrome
Hodgkin’s Lymphoma
Non-Hodgkin’s Lymphomas
Precursor Lymphoid Neoplasms
Systemic or Secondary Mature B-Cell Lymphomas and Leukemias
Primary B-Cell Lymphoid Neoplasms Presenting with Prominent Splenomegaly
Mature T-Cell and NK-Cell Neoplasms
T-Cell Lymphoid Neoplasms Presenting with Prominent Splenomegaly
Myeloid Neoplasms
Systemic Mastocytosis
Proliferations of the Monocyte-Macrophage System
Mesenchymal Tumors and Non-Neoplastic Disorders That Mimic Neoplasms
Inflammatory Pseudotumor-Like Dendritic Cell Sarcoma and Reactive Pseudotumoral Lesions of the Spleen
Splenic Cysts
Other Tumors
Storage Diseases
Pearls and Pitfalls
References
Chapter 61 Diagnosis of Lymphoma in Extranodal Sites Other Than Skin
Nervous System and Meninges
Ocular Adnexa
Waldeyer’s Ring
Nasal Cavity and Paranasal Sinuses
Salivary Gland
Oral Cavity
Thyroid Gland
Larynx
Trachea
Lungs
Pleura and Pleural Cavity
Thymus
Heart
Breast
Gastrointestinal Tract
Appendix
Liver
Gallbladder
Extrahepatic Biliary Tree
Pancreas
Adrenal Gland
Kidney
Ureter
Urinary Bladder and Urethra
Male Genital Tract
Female Genital Tract

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