Immunology and Serology in Laboratory Medicine 1st edition by Mary Louise Turgeon 0323779326 9780323779326

Immunology & Serology in Laboratory Medicine 1st edition by Mary Louise Turgeon – Ebook PDF Instant Download/DeliveryISBN:   0323779326, 9780323779326 

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ISBN-10 ‏ : ‎0323779326 

ISBN-13 ‏ : ‎ 9780323779326

Author: Mary Louise Turgeon 

Building on a solid foundation of knowledge and skills, this classic text from trusted author Mary Louise Turgeon clearly explains everything from basic immunologic mechanisms and serologic concepts to the theory behind procedures performed in the lab. This go-to resource prepares you for everything from mastering automated techniques to understanding immunoassay instrumentation and disorders of infectious and immunologic origin. Packed with learning objectives, review questions, step-by-step procedures, and case studies, this text is the key to your success in today’s modern laboratory environment.

Immunology & Serology in Laboratory Medicine 1st Table of contents:

PART I. Basic Immunologic Mechanisms
1. Highlights of Innate and Adaptive Immune Systems
What is Immunology?
Cells of the Innate and Adaptive Immune Systems
Origin and Development of Blood Cells
Blood and Tissue Cells Associated With Innate and Adaptive Immune Systems
Granulocytes
Mononuclear Phagocyte System
Monocytes
Lymphocyte Variations
Innate Lymphoid Cells
Comparison of Innate and Adaptive Immunity
2. Soluble Mediators of the Immune System
Complement System
Classic Pathway
Alternative Pathway
Mannose-Binding Lectin Pathway
Biological Functions of Complement Proteins
Alterations in Complement Levels
Diagnostic Evaluation
Other Soluble Immune Response Mediators
Hematopoietic Stimulators
Acute-Phase Proteins
3. Antigens and Antibodies
Antigen Characteristics
Chemical Nature of Antigens
Physical Nature of Antigens
General Characteristics of Antibodies
Immunoglobulin (Ig) Classes
Antibody Structure
Immunoglobulin Variants
Antibody Synthesis
Functions of Antibodies
Antigen–Antibody Interaction: Specificity and Cross-Reactivity
Molecular Basis of Antigen–Antibody Reactions
Neutralizing Antibodies
Monoclonal Antibodies
4. Cellular Activities and Clinical Disorders of Innate and Adaptive Immunity
Innate Immunity
Process of Phagocytosis
Neutrophil Extracellular Traps
Monocyte-Macrophage Host Defense Functions
Cytokine Storm Syndromes
Acute Inflammation
Sepsis
Cell Surface Receptors
Disorders of Neutrophils
Monocyte-Macrophage Disorders
Disease States Involving Leukocyte Integrins
Adaptive Immunity
Lymphoid and Nonlymphoid Surface Membrane Markers
Development of T Lymphocytes
Innate Lymphoid Cells
T Regulatory Lymphocytes
B Lymphocytes
Plasma Cell Biology
Alterations in Lymphocyte Subsets
Immunologic Disorders
PART II. The Theory of Immunologic and Serologic Procedures
5. Basic Safety in the Immunology-Serology Laboratory
Safety Standards and Agencies
Safety Manual
Patient Safety
Prevention of Transmission of Infectious Diseases
Safe Work Practices for Infection Control
Protective Techniques for Infection Control
Hand Sanitizing and Handwashing
Other Safety Practices
Laboratory Decontamination
Disposal of Infectious Laboratory Waste
Disease Prevention
6. Basic Quality Control and Quality Assurance Practices
Clinical Laboratory Regulatory and Accrediting Organizations
Nonanalytic Factors Related to Testing Accuracy
Errors Related to Phase of Testing
Quality Descriptors
Monitoring Quality
Reference Range Statistics
Testing Outcomes
Validating New Procedures
7. Basic Serologic Laboratory: Techniques and Clinical Applications
Procedures Manual
Blood Specimen Preparation
Rapid Point-of-Care Testing
8. Precipitation and Particle Agglutination Methods
Principles of Precipitation and Particle Agglutination Assays
Latex Agglutination
Pregnancy Testing
Alternative Procedural Protocols
Flocculation Tests
Direct Bacterial Agglutination
Hemagglutination
Nephelometry
9. Electrophoresis Techniques and Chromatography
Electrophoresis
Serum Protein Electrophoresis
Immunofixation Electrophoresis
Capillary Electrophoresis
Chromatography and Immunochromatography
10. Labeling Techniques in Immunoassay
Immunoassay Formats
Types of Labels
Chemiluminescence
Immunofluorescence
Alternative Labeling Technologies
11. Flow Cytometry
Characteristics of Instrumentation
Flow Cell Cytometry
12. Molecular Laboratory Techniques
Characteristics of Nucleic Acids
Molecular Amplification Methods
Molecular Analysis of Amplification Products
Massively Parallel Sequencing/Next-Generation Sequencing Technology
PART III. Immunologic Manifestations of Infectious Diseases
13. Infectious Diseases: Overview and TORCH Diseases
Characteristics of Infectious Diseases
Development of Infectious Diseases
Traditional Infectious Disease Laboratory Testing
Bacterial Diseases
Parasitic Diseases
Fungal Diseases
Viral, Rickettsial, and Mycoplasmal Diseases
COVID-19 (SARS-CoV-2 Virus)
Dengue Fever
TORCH Test Panel
Toxoplasmosis
Rubella
Rubeola (Measles)
Cytomegalovirus
Herpes Viruses
Alternate Immunology Laboratory Techniques
14. Streptococcal Infections
Etiology
Epidemiology
Signs And Symptoms
Diagnostic Evaluation
Streptococcal Toxic Shock Syndrome
Group B Streptococcal Disease
15. Syphilis
Etiology
Epidemiology
Signs and Symptoms
Primary Syphilis
Secondary Syphilis
Latent Syphilis
Late (Tertiary) Syphilis
Immunologic Manifestations
Diagnostic Evaluation
Direct Observation of Spirochetes
Nontreponemal Methods
Treponemal Methods
Sensitivity of Representative Procedures for Syphilis
Traditional Versus Reverse-Screening Algorithm Protocols
16. Vector-Borne Diseases
Lyme Disease
Human Ehrlichiosis
Rocky Mountain Spotted Fever
Babesiosis
Chikungunya Disease
Dengue Virus
West Nile Virus
Zika Virus
17. Infectious Mononucleosis
Etiology
Epidemiology
Signs and Symptoms
Laboratory Diagnostic Evaluation
Immunologic Manifestations
18. Viral Hepatitis
General Characteristics of Hepatitis
Hepatitis A
Hepatitis B
Hepatitis D
Hepatitis C
Hepatitis E
Hepatitis G
Transfusion-Transmitted Virus
PART IV. Immune Disorders
19. Primary and Acquired Immunodeficiency Syndromes
Primary Immunodeficiency Disorders
Characteristics of Primary Immunodeficiency Disorders
General Laboratory Evaluation
T Cell Immunodeficiency Disorders
Digeorge Syndrome
Severe Combined Immunodeficiency (SCID)
Chronic Mucocutaneous Candidiasis
Bruton X-Linked Agammaglobulinemia
Common Variable Immunodeficiency
Transient Hypogammaglobulinemia of Infancy
Immunodeficiency with Elevated Immunoglobulin M (Hyper-IgM)
Selective Immunoglobulin A Deficiency
X-Linked Lymphoproliferative Disease (XLP) Syndromes 1 and 2 (Duncan Disease)
Combined Cellular Immunodeficiency Disorders
Partial Combined Immune Deficiency Disorders
Other Primary Immune Disorders
Hyper-E Syndrome (Job Syndrome)
Acquired (Secondary) Immunodeficiency Disorders
Acquired Immunodeficiency Syndrome
Prevention
Treatment
Preexposure and Postexposure Prophylaxis
20. Hypersensitivity Reactions
What is Hypersensitivity?
What is an Allergy?
Types of Antigens and Reactions
Types of Hypersensitivity Reactions
Comparison of Types of Hypersensitivity
21. Immunoproliferative Disorders
General Characteristics of Gammopathies
Multiple Myeloma
Waldenström Primary Macroglobulinemia
Other Monoclonal Disorders
22. Tolerance, Autoimmunity, and Autoimmune Disorders
Immunologic Tolerance
Factors Influencing Development of Autoimmunity
Major Autoantibodies
Autoimmune Disease
Innate Immune System
Adaptive Immune Response
Comparison of Organ-Specific and Organ-Nonspecific Autoimmune Disorders
Organ-Specific and Midspectrum Disorders
23. Systemic Lupus Erythematosus
Different Forms of Lupus
Etiology
Epidemiology
Signs and Symptoms
Diagnostic Evaluation
Treatment
24. Rheumatoid Arthritis
Etiology
Epidemiology
Signs and Symptoms
Anatomy and Physiology of Joints
Immunologic Manifestations
Diagnostic Evaluation
Rheumatoid Factor
Cyclic Citrullinated Peptide Antibodies
Juvenile Idiopathic Arthritis
Treatment
Diagnostic Procedures
PART V. Transplantation & Tumor Immunology
25. Transplantation: Human Leukocyte Antigens, Solid Organ, and Hematopoietic Stem Cells
Histocompatibility Antigens
Transplantation Terminology
General Facts About Transplantation
Pretransplantation Screening
Types of Transplants
Sources of Stem Cells for Transplantation
Graft Rejection
Mechanisms of Rejection
Transplantation Complications
Biomarkers for Rejection
FOXP3 Messenger Ribonucleic Acid (MRNA)
Graft-Versus-Host Disease
Current Directions
26. Tumor Immunology and Applications of Massive Parallel Sequencing/Next-Generation Sequencing
Cancer Stem Cells
Types of Tumors
Epidemiology
Causative Factors in Human Cancer
Impact of Somatic Mutations
Stages of Carcinogenesis
Cancer-Predisposing Genes
Proto-Oncogenes
Role of Oncogenes
Body Defenses Against Cancer
Tumor Markers
DNA Microarray Technology
What’s New in Cancer Diagnostic Testing?
Modalities for Treating Cancer
PART VI. Vaccines
27. Primer on Vaccines
Goal of Vaccination
What is a Vaccine?
History of Vaccines
Types of Vaccines
Model of Vaccine Development
Host Response to Vaccination
Development of a Covid-19 Vaccine
Rates of Vaccination
Sites of Vaccine Administration
Representative Diseases Associated With Newer Approved or Investigational Vaccines
Dengue Fever Vaccine
International Travel Vaccines
Cancer Vaccines
Vaccines in Biodefense

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