Ion channels as therapeutic targets, Part A 1st Edition by Rosen Donev 9780128052105 0128052104

Ion channels as therapeutic targets, Part A 1st Edition by Rosen Donev – Ebook Instant Download/Delivery ISBN(s): 9780128047941,9780128052105,0128047941,0128052104

Product details:

• ISBN 10: 0128052104
• ISBN 13: 9780128052105 
•  Author: Rosen Donev

Ion Channels as Therapeutic Targets is the latest volume in the popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics. Provides cutting-edge developments in protein chemistry and structural biology Discusses the use of ion channels as therapeutic targets Chapters are written by authorities in their field Targeted to a wide audience of researchers, specialists, and students

Table contents:

Chapter One: Proteostasis Maintenance of Cys-Loop Receptors
1. Introduction
2. Folding, Assembly, and Degradation of Cys-Loop Receptors in the ER
3. Trafficking of Cys-Loop Receptors from ER to Golgi and to Plasma Membrane
4. Protein Quality Control of Cys-Loop Receptors on the Plasma Membrane
5. Other Regulations of Cys-Loop Receptors
6. Disease and Therapy
Chapter Two: Harnessing the Flow of Excitation: TRP, Voltage-Gated Na+, and Voltage-Gated Ca2 + Channels in Contemporary Medicine
1. Introduction
2. TRP Channels
3. Voltage-Gated Na+ Channels
4. Voltage-Gated Ca2 + Channels
5. Channelopathies of TRP, Nav, and Cav Channels
6. Harnessing the Flow of Excitation in Neural Circuits
7. Conclusion and Perspectives
Chapter Three: Ion Channels in Neurological Disorders
1. Introduction
2. Aberrant Channels in NDDs
3. Therapeutics Approach to Correct Altered Channel Function in NDDs
4. Conclusion
Chapter Four: Acid-Sensing Ion Channels as Potential Pharmacological Targets in Peripheral and Central Nervous System Diseases
1. Acid-Sensing Ion Channels: General View
2. PNS Pathologies: ASICs as a Pharmacological Target
3. CNS Pathologies: ASICs as a Pharmacological Target
4. Conclusions
Chapter Five: Glutamatergic NMDA Receptor as Therapeutic Target for Depression
1. Introduction
2. Glutamatergic System
3. NMDA Receptor Binding and Modulators with Antidepressant Properties
4. Conclusion
Chapter Six: AMPA Receptors as Therapeutic Targets for Neurological Disorders
1. AMPA Receptor Structure and Function
2. Synaptic Plasticity and AMPA Receptor Dynamics
3. AMPA Receptor Interactions with Postsynaptic Density Proteins
4. AMPA Receptors in Neurodegenerative Diseases
5. AMPA Receptors and ASD
6. AMPA Receptors in the Treatment of Drug Addiction
7. AMPA Receptors and Epilepsy
8. Translating Data from Animal Models to the Human Brain
9. Conclusions and Future Directions
Chapter Seven: pH-Sensitive K+ Currents and Properties of K2P Channels in Murine Hippocampal Astrocytes
1. Introduction
2. Materials and Methods
3. Results
4. Discussion
Chapter Eight: SUMOylation and Potassium Channels: Links to Epilepsy and Sudden Death
1. Introduction
2. SUMOylation and De-SUMOylation Machinery
3. SUMOylation and Potassium Ion Channels
4. Role of SUMOylation in Epilepsy and Sudden Death
5. Conclusions and Outlook

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