Long Non-Coding RNA: The Dark Side of the Genome Morillon Antonin 0081023553 9780081023556

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Product details:

• ISBN-10: 0081023553
• ISBN-13: 9780081023556
• Author: Morillon Antonin

The dark side of the genome represents vast domains of the genome that are not encoding for proteins – the basic bricks of cellular structure and metabolism. Up to 98% of the human genome is non-coding and produces so-called long non-coding RNA. Some of these non-coding RNA play fundamental roles in cellular identity, cell development and cancer progression. They are now widely studied in many organisms to understand their function.

This book reviews this expanding field of research and present the broad functional diversities of those molecules and their putative fundamental and therapeutic roles and develops the recent history of non-coding RNA, their very much debated classification and how they raise a formidable interest for developmental and tumorigenesis biology.

Table of contents:

1: Non-coding RNA, Its History and Discovery Timeline
Abstract
1.1 The biology of RNA, a century of history
1.2 The discovery of long non-coding RNA in the pregenomic era
1.3 From the non-coding genome to the non-coding transcriptome, the advent of the genomic era
2: Definition and Families of Long Non-coding RNA
Abstract
2.1 The portrait of an ideal suspect in terms of long non-coding RNA
2.2 Classification of lncRNA
3: Biological Functions of Long Non-coding RNA
Abstract
3.1 Non-coding RNA: rejects or functional elements of genomes?
3.2 Functions of lncRNA in biological diversity
3.3 The classified functions of lncRNA
3.3 Classification based on association with biological processes
4: Non-coding RNA in Development
Abstract
4.1 Inactivation of the X chromosome
4.2 Genomic imprinting
4.3 Regulation of HOX genes
4.4 Pluripotency by preventing the initiation of cell differentiation
4.5 Brain and central nervous system (CNS) development
4.6 Development of other organs
4.7 Development of skin, blood and adipose cells
5: Long Non-coding RNA and Cancer
Abstract
5.1 Identifying the lncRNA signals in cancer transcriptomes
5.2 lncRNA, “drivers” of the cancer phenotype
5.3 lncRNA as diagnostic and prognostic tools and as therapeutic targe

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