Medical Pharmacology & Therapeutics 6th Edition by Derek G. Waller, Andrew W. Hitchings, Anthony P. Sampson – Ebook PDF Instant Download/DeliveryISBN: 0702081612, 9780702081613
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ISBN-10 : 0702081612
ISBN-13 : 9780702081613
Author: Derek G. Waller, Andrew W. Hitchings, Anthony P. Sampson
Medical Pharmacology & Therapeutics provides all the information medical and healthcare students need throughout their degree programme and beyond, including for professional qualifications such as the PSA.
This all-round textbook covers basic pharmacology through to drug prescribing in clinical contexts, covering the pathogenic mechanisms of disease; drug actions, side effects, and the therapeutic principles of drug use. It takes a helpful systems-based approach that orders information according to body systems and disease areas, rather than by drug class.
Now in its sixth edition, the book has been fully updated to include latest scientific understanding of drug action and administration and current best practice in prescribing medications, informed by the latest national guidelines.
Medical Pharmacology & Therapeutics 6th Table of contents:
Section 1 General Principles
Chapter 1 Principles of Pharmacology and Mechanisms of Drug Action
Abstract
Chapter Outline
STUDYING PHARMACOLOGY
RECEPTORS AND RECEPTOR-MEDIATED MECHANISMS
PROPERTIES OF DRUG ACTION
TOLERANCE TO DRUG EFFECTS
GENETIC VARIATION IN DRUG RESPONSES
SUMMARY
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 2 Pharmacokinetics
Abstract
Chapter Outline
THE BIOLOGICAL BASIS OF CLINICAL PHARMACOKINETICS
ABSORPTION
DISTRIBUTION
ELIMINATION
THE MATHEMATICAL BASIS OF CLINICAL PHARMACOKINETICS
PHARMACOKINETICS OF BIOLOGICAL DRUGS
GENETIC VARIATION AND PHARMACOKINETICS
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 3 Drug Discovery, Safety and Efficacy
Abstract
Chapter Outline
DRUG DISCOVERY
DRUG APPROVAL
ESTABLISHING SAFETY AND EFFICACY
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 4 Neurotransmission and the Peripheral Autonomic Nervous System
Abstract
Chapter Outline
THE CENTRAL AND PERIPHERAL NERVOUS SYSTEMS
PRINCIPLES OF NEUROTRANSMISSION
THE PARASYMPATHETIC NERVOUS SYSTEM AND CHOLINERGIC TRANSMISSION
OTHER TRANSMITTERS IN THE PERIPHERAL NERVOUS SYSTEM
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Section 2 The Cardiovascular System
Chapter 5 Ischaemic Heart Disease
Abstract
Chapter Outline
MYOCARDIAL PERFUSION
CLINICAL MANIFESTATIONS OF MYOCARDIAL ISCHAEMIA
DRUGS FOR TREATING ANGINA
MANAGEMENT OF STABLE ANGINA
MANAGEMENT OF ACUTE CORONARY SYNDROMES
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 6 Systemic and Pulmonary Hypertension
Abstract
Chapter Outline
SYSTEMIC HYPERTENSION
ANTIHYPERTENSIVE DRUGS
PULMONARY ARTERIAL HYPERTENSION
SELF-ASSESSMENT
CASE-BASED QUESTION
ANSWERS
FURTHER READING
Chapter 7 Heart Failure and Shock
Abstract
Chapter Outline
MAINTENANCE OF CARDIAC OUTPUT
PATHOPHYSIOLOGY OF HEART FAILURE
SHOCK
INOTROPIC AND SYMPATHOMIMETIC DRUGS FOR THE TREATMENT OF HEART FAILURE AND SHOCK
MANAGEMENT OF HEART FAILURE
MANAGEMENT OF SHOCK
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 8 Cardiac Arrhythmias
Abstract
Chapter Outline
BASIC CARDIAC ELECTROPHYSIOLOGY
MECHANISMS OF TACHYARRHYTHMOGENESIS
MECHANISMS OF ACTION AND CLASSIFICATION OF ANTIARRHYTHMIC DRUGS
DRUG TREATMENT OF ARRHYTHMIAS
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 9 Cerebrovascular Disease and Dementia
Chapter Outline
STROKE
SUBARACHNOID HAEMORRHAGE
DEMENTIA
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 10 Peripheral Artery Disease
Abstract
Chapter Outline
ATHEROMATOUS PERIPHERAL ARTERY DISEASE
ACUTE AND CRITICAL LIMB ISCHAEMIA
RAYNAUD’S PHENOMENON
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 11 Haemostasis
Abstract
Chapter Outline
PLATELETS AND PLATELET AGGREGATION
BLOOD COAGULATION AND THE COAGULATION CASCADE
ANTIPLATELET DRUGS
CLINICAL USES OF ANTIPLATELET DRUGS
ANTICOAGULANT DRUGS
CLINICAL USES OF ANTICOAGULANTS
THE FIBRINOLYTIC SYSTEM
CLINICAL USES OF ANTIFIBRINOLYTIC AND HAEMOSTATIC AGENTS
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Section 3 The Respiratory System
Chapter 12 Asthma and Chronic Obstructive Pulmonary Disease
Abstract
Chapter Outline
ASTHMA
CHRONIC OBSTRUCTIVE PULMONARY DISEASE
DRUGS FOR ASTHMA AND CHRONIC OBSTRUCTIVE PULMONARY DISEASE
MANAGEMENT OF ASTHMA
MANAGEMENT OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 13 Respiratory Disorders: Cough, Respiratory Stimulants, Cystic Fibrosis, Idiopathic Pulmonary Fibrosis and Neonatal Respiratory Distress Syndrome
Abstract
Chapter Outline
COUGH
RESPIRATORY STIMULANTS (ANALEPTIC DRUGS)
CYSTIC FIBROSIS
IDIOPATHIC PULMONARY FIBROSIS
NEONATAL RESPIRATORY DISTRESS SYNDROME
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Section 4 The Renal System
Chapter 14 Diuretics
Abstract
Chapter Outline
FUNCTIONS OF THE KIDNEY
DIURETIC DRUGS
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 15 Disorders of Micturition
Abstract
Chapter Outline
PATHOPHYSIOLOGY OF MICTURITION
OVERACTIVE BLADDER AND URGE URINARY INCONTINENCE
HYPOTONIC BLADDER
URETHRAL SPHINCTER INCOMPETENCE
LOWER URINARY TRACT SYMPTOMS IN MEN AND BENIGN PROSTATE ENLARGEMENT
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 16 Erectile Dysfunction
Abstract
Chapter Outline
PHYSIOLOGY OF ERECTION
DRUGS FOR ERECTILE DYSFUNCTION
MANAGEMENT OF ERECTILE DYSFUNCTION
PREMATURE EJACULATION
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Section 5 The Nervous System
Chapter 17 General Anaesthetics
Abstract
Chapter Outline
MECHANISMS OF ACTION OF GENERAL ANAESTHETICS
DRUGS USED IN ANAESTHESIA
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 18 Local Anaesthetics
Abstract
Chapter Outline
PHARMACOLOGY
TECHNIQUES OF ADMINISTRATION
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 19 Opioid Analgesics and the Management of Pain
Abstract
Chapter Outline
PAIN AND PAIN PERCEPTION
ANALGESIC DRUGS
PAIN MANAGEMENT
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 20 Anxiety, Obsessive-Compulsive Disorder and Insomnia
Abstract
Chapter Outline
ANXIETY DISORDERS
OBSESSIVE-COMPULSIVE DISORDER
INSOMNIA
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 21 Schizophrenia and Bipolar Disorder
Abstract
Chapter Outline
SCHIZOPHRENIA
ANTIPSYCHOTIC DRUGS
MANIA AND BIPOLAR DISORDER
MOOD-STABILISING DRUGS FOR BIPOLAR DISORDER
MANAGEMENT OF BIPOLAR DISORDER
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 22 Depression, Attention Deficit Hyperactivity Disorder and Narcolepsy
Abstract
Chapter Outline
DEPRESSION
SELF-ASSESSMENT
ANSWERS
Chapter 23 Seizures and Epilepsy
Abstract
Chapter Outline
PATHOLOGICAL BASIS OF SEIZURES AND EPILEPSY
MANAGEMENT OF EPILEPSY
SELF-ASSESSMENT
ANSWERS
Chapter 24 Extrapyramidal Movement Disorders and Spasticity
Abstract
Chapter Outline
THE BASAL GANGLIA AND CONTROL OF MOTOR FUNCTION
PARKINSON’S DISEASE AND RELATED SYNDROMES
DRUGS FOR PARKINSON’S DISEASE
MANAGEMENT OF PARKINSON’S DISEASE AND RELATED SYNDROMES
OTHER INVOLUNTARY MOVEMENT DISORDERS (DYSKINESIAS)
MANAGEMENT OF DYSKINESIAS AND DYSTONIAS
SPASTICITY
MANAGEMENT OF SPASTICITY
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 25 Other Neurological Disorders: Multiple Sclerosis, Motor Neuron Disease and Guillain–Barré Syndrome
Abstract
Chapter Outline
MULTIPLE SCLEROSIS
MOTOR NEURON DISEASE
GUILLAIN–BARRÉ SYNDROME
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 26 Migraine and Other Headaches
Abstract
Chapter Outline
MIGRAINE
PATHOGENESIS OF MIGRAINE
DRUGS FOR MIGRAINE
MANAGEMENT OF MIGRAINE AND OTHER HEADACHES
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Section 6 The Musculoskeletal System
Chapter 27 The Neuromuscular Junction and Neuromuscular Blockade
Abstract
Chapter Outline
NEUROMUSCULAR TRANSMISSION
DRUGS ACTING AT THE NEUROMUSCULAR JUNCTION
INDICATIONS FOR NEUROMUSCULAR-BLOCKING DRUGS
ANTAGONISING NEUROMUSCULAR BLOCK
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 28 Myasthenia Gravis
Abstract
Chapter Outline
ACETYLCHOLINESTERASE (AChE) INHIBITORS
MANAGEMENT OF MYASTHENIA GRAVIS
LAMBERT–EATON MYASTHENIC SYNDROME
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 29 Nonsteroidal Antiinflammatory Drugs
Abstract
Chapter Outline
THE ROLE OF CYCLOOXYGENASE ENZYMES IN THE ACTIONS OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS
NONSTEROIDAL ANTIINFLAMMATORY DRUGS (NSAIDs)
INDICATIONS FOR USING NONSTEROIDAL ANTIINFLAMMATORY DRUGS
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 30 Rheumatoid Arthritis, Other Inflammatory Arthritides and Osteoarthritis
Abstract
Chapter Outline
RHEUMATOID ARTHRITIS
OTHER TYPES OF INFLAMMATORY ARTHRITIS: THE SPONDYLOARTHROPATHIES
DRUGS FOR TREATMENT OF INFLAMMATORY ARTHRITIS
MANAGEMENT OF RHEUMATOID ARTHRITIS
MANAGEMENT OF SPONDYLOARTHROPATHIES
OSTEOARTHRITIS
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 31 Hyperuricaemia, Gout and Pseudogout
Abstract
Chapter Outline
THE PATHOPHYSIOLOGY OF GOUT
DRUGS FOR THE TREATMENT OF GOUT AND PREVENTION OF HYPERURICAEMIA
TREATMENT OF GOUT
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Section 7 The Gastrointestinal System
Chapter 32 Nausea and Vomiting
Abstract
Chapter Outline
NAUSEA AND VOMITING
VERTIGO
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 33 Dyspepsia, Peptic Ulcer Disease and Gastrooesophageal Reflux Disease
Abstract
Chapter Outline
THE SPECTRUM OF DISEASE
CONTROL OF GASTRIC ACID SECRETION
DRUGS FOR TREATING DYSPEPSIA, PEPTIC ULCER AND GASTROOESOPHAGEAL REFLUX DISEASE
MANAGEMENT OF DYSPEPSIA, PEPTIC ULCER AND GASTROOESOPHAGEAL REFLUX DISEASE
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 34 Inflammatory Bowel Disease
Abstract
Chapter Outline
INFLAMMATORY BOWEL DISEASE
DRUGS FOR INFLAMMATORY BOWEL DISEASE
MANAGEMENT OF INFLAMMATORY BOWEL DISEASE
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 35 Constipation, Diarrhoea and Irritable Bowel Syndrome
Abstract
Chapter Outline
CONSTIPATION
DIARRHOEA
IRRITABLE BOWEL SYNDROME
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 36 Liver Disease
Abstract
Chapter Outline
ACUTE LIVER FAILURE
CHRONIC LIVER DISEASE AND LIVER CIRRHOSIS
AUTOIMMUNE HEPATITIS
PRIMARY BILIARY CHOLANGITIS
CHRONIC VIRAL HEPATITIS
COMPLICATIONS OF DECOMPENSATED CIRRHOSIS
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 37 Obesity
Abstract
Chapter Outline
PATHOGENESIS OF OBESITY
DRUGS FOR TREATMENT OF OBESITY
MANAGEMENT OF OBESITY
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Section 8 The Immune System
Chapter 38 The Immune Response and Immunosuppressant Drugs
Abstract
Chapter Outline
BIOLOGICAL BASIS OF THE IMMUNE RESPONSE
IMMUNOSUPPRESSANT DRUGS
IMMUNOSUPPRESSION IN INFLAMMATORY AND AUTOIMMUNE DISEASE
IMMUNOSUPPRESSION IN ORGAN TRANSPLANTATION
LONG-TERM EFFECTS OF IMMUNOSUPPRESSION
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 39 Antihistamines and Allergic Disease
Abstract
Chapter Outline
ATOPY, ALLERGIC DISORDERS AND ANAPHYLAXIS
HISTAMINE AS AN AUTACOID IN HOST DEFENCE
HISTAMINE H1 RECEPTOR ANTAGONISTS (ANTIHISTAMINES)
MECHANISMS OF ACTION AND EFFECTS
MANAGEMENT OF ALLERGIC DISORDERS
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Section 9 The Endocrine System and Metabolism
Chapter 40 Diabetes Mellitus
Abstract
Chapter Outline
CONTROL OF BLOOD GLUCOSE
DIABETES MELLITUS
INSULIN AND INSULIN ANALOGUES FOR TREATMENT OF DIABETES MELLITUS
OTHER PARENTERAL GLUCOSE-LOWERING DRUGS
ORAL GLUCOSE-LOWERING DRUGS
DRUGS TO INCREASE PLASMA GLUCOSE LEVELS
MANAGEMENT OF TYPE 1 DIABETES MELLITUS
MANAGEMENT OF TYPE 2 DIABETES MELLITUS
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 41 The Thyroid and Control of Metabolic Rate
Abstract
Chapter Outline
THYROID FUNCTION
THYROTOXICOSIS
HYPOTHYROIDISM
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 42 Calcium Metabolism and Metabolic Bone Disease
Abstract
Chapter Outline
PHYSIOLOGY OF BONE TURNOVER
HYPERCALCAEMIA
HYPOCALCAEMIA
METABOLIC BONE DISEASE
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 43 Pituitary and Hypothalamic Hormones
Abstract
Chapter Outline
ANTERIOR PITUITARY AND RELATED HYPOTHALAMIC HORMONES
POSTERIOR PITUITARY HORMONES
HYPOPITUITARISM
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 44 Corticosteroids (Glucocorticoids and Mineralocorticoids)
Abstract
Chapter Outline
CORTICOSTEROID HORMONES
GLUCOCORTICOIDS
MINERALOCORTICOIDS
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 45 Female Reproduction
Abstract
Chapter Outline
PHYSIOLOGY OF THE MENSTRUAL CYCLE
PHYSIOLOGY OF PREGNANCY
STEROIDAL CONTRACEPTIVES
THE MENOPAUSE
PREGNANCY AND LABOUR
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 46 Androgens, Antiandrogens and Anabolic Steroids
Abstract
Chapter Outline
ANDROGENS AND ANABOLIC STEROIDS
ANABOLIC STEROIDS
ANTIANDROGENS
5α-REDUCTASE INHIBITORS
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 47 Anaemia and Haematopoietic Colony-Stimulating Factors
Abstract
Chapter Outline
ANAEMIA
NEUTROPENIA
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 48 Lipid Disorders
Abstract
Chapter Outline
LIPIDS AND LIPOPROTEINS
FORMATION OF ATHEROMA
DRUGS FOR HYPERLIPIDAEMIAS
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Section 10 The Skin and Eyes
Chapter 49 Skin Disorders
Abstract
Chapter Outline
VEHICLES FOR TOPICAL SKIN APPLICATIONS
ATOPIC AND CONTACT DERMATITIS
PSORIASIS
ACNE VULGARIS
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 50 The Eye
Abstract
Chapter Outline
TOPICAL APPLICATION OF DRUGS TO THE EYE
MYDRIATIC AND CYCLOPLEGIC DRUGS
GLAUCOMA
OTHER DRUGS ADMINISTERED TOPICALLY TO THE EYE
DRY EYE SYNDROME
AGE-RELATED MACULAR DEGENERATION
DIABETIC RETINOPATHY
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Section 11 Antimicrobial Therapy
Chapter 51 Drugs for Infections
Abstract
Chapter Outline
BACTERIAL INFECTIONS
FUNGAL INFECTIONS
VIRAL INFECTIONS
PROTOZOAL INFECTIONS
HELMINTHIC INFECTIONS
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Section 12 Cancer
Chapter 52 Drugs for Cancer
Abstract
Chapter Outline
THE BIOLOGY OF CANCER
CYTOTOXIC ANTICANCER DRUGS
MECHANISMS OF ACTION
SPECIFIC CYTOTOXIC ANTICANCER DRUGS
TARGETED ANTICANCER DRUGS
CLINICAL USES OF ANTICANCER DRUGS
ANTICANCER DRUG THERAPY FOR SPECIFIC MALIGNANCIES
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Section 13 General Features: Toxicity and Prescribing
Chapter 53 Drug Toxicity and Overdose
Abstract
Chapter Outline
DRUG TOXICITY AND ADVERSE EFFECTS
SELF-POISONING AND DRUG OVERDOSE
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 54 Substance Abuse and Dependence
Abstract
Chapter Outline
THE BIOLOGICAL BASIS OF DEPENDENCE
DRUGS OF ABUSE
SELF-ASSESSMENT
ANSWERS
FURTHER READING
Chapter 55 Prescribing, Adherence and Information About Medicines
Abstract
Chapter Outline
DUTIES OF THE PRESCRIBER
GENERIC PRESCRIBING
DOSAGE
ADHERENCE, CONCORDANCE AND COMPLIANCE
INFORMING PEOPLE ABOUT THEIR MEDICINES
RATIONAL PRESCRIBING
THE PRESCRIBING SAFETY ASSESSMENT (PSA)
FURTHER READING
Chapter 56 Drug Therapy in Special Situations
Abstract
Chapter Outline
PRESCRIBING IN PREGNANCY
DRUGS AND BREASTFEEDING
PRESCRIBING FOR CHILDREN
PRESCRIBING FOR OLDER PEOPLE
PRESCRIBING IN RENAL FAILURE
PRESCRIBING IN LIVER DISEASE
PRESCRIBING IN PALLIATIVE CARE
DRUG INTERACTIONS
SELF-ASSESSMENT
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