Molecular, Cellular, and Metabolic Fundamentals of Human Aging 1st Edition

Molecular, Cellular, and Metabolic Fundamentals of Human Aging 1st Edition – Ebook Instant Download/Delivery ISBN(s): 9780323916189,032391618X

Product details:

• ISBN 10: 032391618X
• ISBN 13: 9780323916189
• Author: Evandro Fei Fang, Linda Hildegard Bergersen, Brian C. Gilmour

Molecular, Cellular, and Metabolic Fundamentals of Human Aging provides researchers with an overview of the main aging mechanisms and physiology and how they can lead to age-related diseases and conditions. Topics covered include DNA damage and how ineffective repair can lead to cell and tissue aging and decreased functionality, loss of proteostasis, changes to feeding and fasting pathways, mitochondrial dysfunction, the impact of decreased ability of autophagosomes and autophagosomes, cellular senescence, changes to communication molecules, and the impact of stem cell exhaustion.

Table contents:

Chapter 1. The hallmarks of aging: decoding aging’s mystery

1. Aging

2. Aging research

3. Life span and health span

4. The hallmarks of aging

Section I. The genome

Chapter 2. Epigenetic aging and its reversal

1. Introduction to epigenetics

2. Changes in chromatin structure during aging

3. Changes in histones during aging

4. Changes in histone posttranslational modifications

5. Deoxyribonucleic acid methylation in aging

6. Noncoding ribonucleic acids in aging

7. Reversal of epigenetic aging

8. Conclusions and perspectives

Section II. Metabolism, homeostasis, and communication

Chapter 3. Nutrient sensing and aging

1. AMPK signaling pathway

2. mTOR pathway

3. SIRT pathway

4. IGF-1 pathway

5. Calorie restriction and aging

6. Conclusion

Chapter 4. Dysregulated proteostasis: mechanisms and links to aging

1. Introduction

2. Functional modules of the proteostasis network

3. Proteostasis network dysregulation in aging

4. Interplay with other aging hallmarks

5. Targeting proteostasis for healthy aging

6. Concluding remarks

Section III. Autophagy and bioenergetics

Chapter 5. Autophagy and bioenergetics in aging

1. Compromised autophagy and mitophagy in aging and disease

2. Mitochondrial dysfunction

3. Mechanisms of mitochondrial dysfunction

4. Dysfunctional mitochondria contribute to energy shortages and aging cells

5. Conclusions and future perspectives

Section IV. Senescence

Chapter 6. Senescence in aging

1. What is senescence?

2. Current concepts of senescence in aging

3. Factors driving and/or triggering senescence in aging

4. Stem cell exhaustion in aging

5. To develop senotherapies (senolytics and senomorphics) against age-related diseases and beyond

6. Methods for analyzing and quantifying senescence in vitro and in vivo

7. Concluding remarks

Section V. Applications

Chapter 7. Aging and the immune system

1. Overview of immunosenescence

2. Aging-related lymphoid organs and immunity

3. Interplay between immunosenescence and aging process

4. Conclusions

Chapter 8. Canonical and novel strategies to delay or reverse aging

1. Approaching aging as a treatable disease

2. Nonpharmaceutical interventions against aging

3. Pharmaceutical treatments against aging

4. Novel approaches to slow or reverse aging

5. Outstanding questions and future perspectives

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