Nanopharmaceuticals: Expectations and Realities of Multifunctional Drug Delivery Systems: Volume 1: Expectations and Realities of Multifunctional Drug Delivery Systems 1st Edition by Ranjita Shegokar 0128177799 9780128177792

Nanopharmaceuticals: Expectations and Realities of Multifunctional Drug Delivery Systems: Volume 1: Expectations and Realities of Multifunctional Drug Delivery Systems 1st Edition by Ranjita Shegokar – Ebook PDF Instant Download/DeliveryISBN:   0128177799, 9780128177792 

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Product details:

ISBN-10 :  0128177799 

ISBN-13 :  978018177792

Author :  Ranjita Shegokar 

Nanopharmaceuticals reviews advances in the drug delivery field via nanovehicles or nanocarriers that offer benefits like targeted therapy and serves as a single dose magic bullet for multiple drug delivery with improved drug efficiency at a lower dose, transportation of the drug across physiological barriers as well as reduced drug-related toxicity. The chapters are written by a diverse group of international researchers from industry and academia.

The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers.

 

Nanopharmaceuticals: Expectations and Realities of Multifunctional Drug Delivery Systems: Volume 1: Expectations and Realities of Multifunctional Drug Delivery Systems 1st Table of contents:

Chapter 1. Solid lipid nanoparticles (SLN): prediction of toxicity, metabolism, fate and physicochemical properties
1. Introduction
2. Toxicity profiling
3. Physicochemical properties
4. Administration routes and drug bioavailability
5. Conclusions
Abbreviations
Chapter 2. Role of nanocarriers and their surface modification in targeting delivery of bioactive compounds
1. Bioactive compounds as promising therapeutic agents
2. Complexity of bioactive compounds
3. Biological barriers
4. Nanocarrier: a strategy to overcome biological barriers
5. Safe-by-design bioactive-loaded nanocarrier system development
6. Cellular uptake capability of bioactive-loaded nanocarrier system
7. Surface modification of nanocarriers
8. Biokinetic profile of bioactive-loaded nanocarriers
9. Challenges of bioactive-loaded nanocarrier to clinical translation
10. Conclusion
Chapter 3. Polymeric nanomicelles as versatile tool for multidrug delivery in chemotherapy
1. Introduction
2. Micelles, principles and characterization
3. Polymeric micelles for codelivery of chemotherapeutics
4. Stimuli-responsive codelivery of polymeric micelles
5. Targeted codelivery of polymeric micelles
6. Application of polymeric micelles in codelivery for multiple therapies
7. Conclusions
Chapter 4. Nanoparticulate systems for wound healing
1. Introduction
2. Lipid-based nanoparticles
3. Inorganic nanoparticles
4. Conclusions
Chapter 5. Solid dispersions: technologies used and future outlook
1. Introduction
2. Classification of solid dispersions
3. Structure-based classification of solid dispersion
4. Drug release mechanism from SDs
5. Applications of SDs
6. Challenges in SD development
7. Techniques for solid dispersions generation
8. Future outlook
9. Conclusion
Abbreviations
Chapter 6. Nanotoxicity: the impact of increasing drug bioavailability
1. Introduction
2. Nanomedicines, absorption and theranostics
3. Risk assessment process
4. In vitro toxicity
5. In vitro assay interferences
6. Genotoxicity
7. Immunotoxicity
8. Dermal toxicity
9. Nephrotoxicity
10. Liver toxicity
11. Brain toxicity
12. Prediction in vivo of human response to nanomaterials
13. ADME model
14. Organ-on-chip systems
15. Whole-animal models
16. Regulation of nanotechnology products
17. Conclusions and perspectives
Chapter 7. Nanoparticle-based vaccines: opportunities and limitations
1. Chapter outline
2. Conclusion
Chapter 8. Lipid nanocarriers for delivery of poorly soluble and poorly permeable drugs
1. Introduction
2. Biopharmaceutics Classification System—implications for drug delivery
3. Classification and composition of lipid nanocarriers for oral drug delivery
4. Types of lipid nanocarriers for oral drug delivery
5. Solubility and permeability enhancement strategies by lipid nanocarriers
6. Mechanisms of interaction of lipid nanocarriers with cell membranes
7. Conclusion and future perspectives
Chapter 9. Nose-to-brain drug delivery: an alternative approach for effective brain drug targeting
1. Introduction
2. Common brain disorders
3. Anatomy of the nasal cavity
4. Nose-to-brain drug transport pathways
5. Strategies to enhance nasal absorption
6. Novel drug delivery approaches
7. Recent advancements in the clinical trials of nanoparticles via the nose-to-brain delivery
8. Summary
Chapter 10. Trends in the intellectual property (IP) landscape of drug delivery systems: 30 years of growth and evolution
1. Introduction
2. Overview of the IP landscape for drug delivery systems
3. Trends in oral drug delivery IP
4. Trends in topical drug delivery IP
5. Trends in parenteral drug delivery IP
6. Emerging trends in drug delivery IP
7. IP monitoring strategies
8. Conclusion

 

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Nanopharmaceuticals,Expectations,Realities,Multifunctional