(EBook PDF) Neuroplasticity From Bench to Bedside 1st Edition by Angelo Quartarone 0128194111 9780128194119 full chapters

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ISBN-10 ‏ : ‎0128194111 

ISBN-13 ‏ : ‎ 9780128194119

Author:  Angelo Quartarone 

Neuroplasticity: From Bench to Bedside, Volume 184 in the Handbook of Clinical Neurology series, provides a comprehensive multidisciplinary guide to neuroplasticity. Sections summarize the basic mechanisms of neuroplasticity, focus on neuroplasticity in movement disorders, discuss brain oscillations in neurological disorders, segue into plasticity in neurorehabilitation, and cover issues of inflammation and autoimmunity in neuroplasticity. The book concludes with a section on neuroplasticity and psychiatric disorders.

• Covers basic mechanisms and clinical treatment approaches in neurological disorders
• Includes inflammation, autoimmunity, genetics, neurophysiology, and more
• Encompasses stroke, Alzheimer’s, movement and psychiatric disorders
• Provides tools for enhancing recovery

 

Neuroplasticity: From Bench to Bedside 1st Table of contents:

Section I: Introduction
Chapter 1: Defining neuroplasticity
Abstract
Introduction
Developmental Plasticity
Myelin Plasticity
Adult Plasticity
Adaptive vs Maladaptive Plasticity
Conclusions
Acknowledgments
References
Section II: Neuroplasticity: Basic mechanism and assessment at system level
Chapter 2: Basic mechanisms of plasticity and learning
Abstract
Introduction
Synaptic and Neuronal Basis of Learning and Memory
Molecular Mechanisms of Synaptic Long-Term Changes: Lessons From the Hippocampus
The Nucleus Striatum and the Dopaminergic Regulation of Synaptic Plasticity
From Bench to Bedside: Synaptic Plasticity Failure in Neurologic Disorders
Conclusions
References
Chapter 3: Local sleep: A new concept in brain plasticity
Abstract
Introduction
Global Changes in Brain Activity During Sleep
Slow Waves and Spindles
Local Patterns of Brain Activity During Sleep
Local, Experience-Dependent Regulation of Sleep Slow Waves
Sleep Slow Wave Activity as a Marker of Brain Structural Adaptations
Experience-Dependent Local Sleep During Wakefulness
Local Regulation of Sleep in Pathologic Conditions
Approaches for the Modulation of Sleep Slow Waves
Conclusions and Future Directions
References
Chapter 4: Sleep and homeostatic control of plasticity
Abstract
Introduction
Sleep, Homeostasis and Plasticity
The Homeostatic Control of Plasticity During Sleep
Multidimensional Assessment of Sleep and Homeostatic Control of Plasticity
Implications Of neural Plasticity and Sleep Homeostasis for the Diagnosis and Treatment of Sleep Disorders
Concluding Remarks
References
Chapter 5: Transcranial magnetic stimulation as a tool to induce and explore plasticity in humans
Abstract
Introduction
Theta Burst Stimulation (TBS)
Paired Associative Stimulation (PAS)
Transcranial Direct Current Stimulation (tDCS)
Metaplasticity
Variability in Brain Stimulation Protocols
Future Perspectives and Conclusions
References
Chapter 6: EEG as a marker of brain plasticity in clinical applications
Abstract
Introduction
Plasticity in Normal Subjects is Defined by Learning and Environmental Changes
Plasticity in Neurologic Diseases
Conclusion and Future Perspectives
References
Further reading
Chapter 7: Tools to explore neuroplasticity in humans: Combining interventional neurophysiology with functional and structural magnetic resonance imaging and spectroscopy
Abstract
Introduction
The Combination of NTBS and Neuroimaging Creates Mutual Benefits
Matchmaking Between Brain Stimulation and Imaging
“Offline Approach”: Informing and Evaluating Stimulation After-Effects With MRI
“Online Approach”: Ensuring and Evaluating State-Dependent Engagement With MRI
Possibilities and Perspectives for Neuroimaging and Brain Stimulation Techniques
Concluding Remarks
References
Chapter 8: Metabolic imaging and plasticity
Abstract
Introduction to Metabolic Imaging
Identifying Regional Metabolic Abnormality: A Univariate Approach
Understanding the Brain Networks: A Methodological Perspective
Abnormal Brain Networks in Movement Disorders
Dissecting Adaptive and Maladaptive Changes
Investigating Neuroplasticity
Conclusions
Acknowledgments
References
Section III: Neuroplasticity in movement disorders
Chapter 9: Parkinson’s disease: Alterations of motor plasticity and motor learning
Abstract
Introduction
Motor Learning in PD
Motor Cortical Plasticity in PD
Cerebellar Modulation of Plasticity in PD
Connection Between the Basal Ganglia and M1
Cortical Plasticity Studies Using TBS Protocols
Cortical Plasticity Studied With Standard rtms Protocols
rTMS as Treatment for Motor Symptoms
Treatment of Depression and Other Nonmotor Symptoms in PD
Deep TMS
Transcranial Direct Current Stimulation (tDCS) in PD
Transcranial Alternating Current Stimulation (tACS) in PD
Concluding Remarks
References
Further reading
Chapter 10: Alpha-synuclein and cortico-striatal plasticity in animal models of Parkinson disease
Abstract
Introduction
Structure and Conformational Properties of α-Synuclein
The Relationship Between Gene Mutations and the Development of Parkinson’s Disease
The Fields of Action of Alpha-Synuclein
The Postsynaptic Functions of α-Synuclein
Conclusions
Acknowledgments
References
Chapter 11: Plasticity, genetics, and epigenetics in l-dopa-induced dyskinesias
Abstract
Introduction
LIDs Pathophysiology and Aberrant Plasticity
Genetics of LIDs
Epigenetics of LIDs
Conclusions
References
Chapter 12: Noninvasive neuromodulation in Parkinson’s disease: Neuroplasticity implication and therapeutic perspectives
Abstract
Introduction
The Contribution of NIBS to the Understanding of PD Pathophysiology
The Rationale for Using Brain Stimulation for Treatment of PD
Clinical Effects of Stimulation Techniques in PD: The State of the Art
Conclusions, Research Needs and Future Perspectives
References
Chapter 13: Plasticity, genetics and epigenetics in dystonia: An update
Abstract
Introduction
Modeling of Dystonia
Synaptic Plasticity in the Basal Ganglia
Abnormal Striatal Plasticity in a Mouse Model of DYT1 Dystonia
Epigenetics
Therapeutical Targets and Clinical Trials
Conclusions
References
Chapter 14: Neuroplasticity in dystonia: Motor symptoms and beyond
Abstract
Introduction
Motor Symptoms and Plasticity
Non motor symptoms of dystonias and plasticity
Conclusions
References
Section IV: Brain oscillations in neurological disorders
Chapter 15: General principles of brain electromagnetic rhythmic oscillations and implications for neuroplasticity
Abstract
Introduction
Conclusions
Acknowledgment
References
Chapter 16: Noninvasive brain stimulation and brain oscillations
Abstract
Brain Oscillations and Behavior
Brain Oscillations in Brain Disorders and Their Modulation
Transcranial Alternating Current Stimulation
Transcranial Direct Current Stimulation
References
Chapter 17: Brain oscillatory dysfunctions in dystonia
Abstract
Clinical Presentation and Treatment Options for Dystonia
Intracerebral Recordings From Human Basal Ganglia
Pattern Changes in Multiunit Activity Reflect Altered Output of Subcortical Structures
Abnormal Oscillatory Pattern as a Sign of Pathologic Input to Basal Ganglia Nuclei
Impaired Network Connectivity Shown by Simultaneous Cortical and Subcortical Recordings
Local and Distant Effects of Deep Brain Stimulation on Oscillations
Perspectives
References
Chapter 18: Brain oscillations and Parkinson disease
Abstract
Introduction
OFF-Medication Theta Oscillations
ON-Medication Theta Oscillations
Beta Oscillations
Gamma Oscillations
High-Frequency Oscillations (HFOs)
Brain Oscillations and DBS
Conclusions
References
Chapter 19: Adaptive deep brain stimulation: Retuning Parkinson’s disease
Abstract
Introduction
Input Signals: The different approaches to aDBS
Concluding Remarks
References
Section V: Plasticity and rehabilitation
Chapter 20: Biomarkers of plasticity for stroke recovery
Abstract
Introduction
Spontaneous Biological Recovery
Plasticity After Stroke
Therapeutic Opportunities
Biomarkers in Stroke Recovery
Structural Imaging for Prediction
Functional Imaging for Prediction
Biomarkers of Recovery Mechanisms
Conclusions
References
Chapter 21: New tools for shaping plasticity to enhance recovery after stroke
Abstract
Introduction
Functional Recovery After Stroke: The Role of Neuroplasticity
Transcranial Magnetic Stimulation
Transcranial Electrical Stimulation
Transcranial Direct Current Stimulation
Transcranial Alternating Current Stimulation
Transcranial Random Noise Stimulation
Vagal Nerve Stimulation
Extremely Low-Frequency Magnetic Fields
Conclusions
References
Chapter 22: Neuroplasticity of spinal cord injury and repair
Abstract
Introduction
Normal Organization of the Descending Motor Pathways and Spinal Motor Systems
Activity-Dependent Corticospinal Tract and Proprioceptive Afferent Plasticity in the Healthy Spinal Cord
Neuropathologic Changes After SCI
Maladaptive Plasticity Underlying Motor Impairment After SCI
Neural Activity-Dependent Plasticity to Repair Spinal Cord Motor Circuits
Combining Plasticity Mechanisms to Restore Function After SCI
Overall Conclusions
References
Chapter 23: Reward and plasticity: Implications for neurorehabilitation
Abstract
Neuroplasticity in Rehabilitation
Principles of Motor Learning
What is a Reward?
Reward and Feedback
Neural Events Associated With Reward Presentation
Reward and Motor Learning
Reward and Rehabilitation
Conclusion
References
Chapter 24: Rehabilitation in movement disorders: From basic mechanisms to clinical strategies
Abstract
Dysfunctional Plasticity in Movement Disorders
Harnessing Plasticity Through Rehabilitation in Movement Disorders
Rehabilitative Interventions in Movement Disorders
Concluding Remarks
References
Chapter 25: Rehabilitation of visual perception in cortical blindness
Abstract
Background
Approaches to Visual Rehabilitation for Cortical Blindness
Measuring Vision Loss after Occipital Stroke
Natural History of Occipital Stroke: Recent Insights into the Dynamics of Vision Loss
Preserved Visual Pathways: Substrates for Visual Rehabilitation
Use of Vision Restoration Training in Cortical Blindness (Figs. 25.1B and 25.2)
Limitations of Training in the Chronic Period After Occipital Stroke
Mounting Evidence for Benefits of Earlier Intervention After V1 Stroke
Safety of Vision Training Early after Stroke
Adjuvants to Behavioral Training for Vision Rehabilitation
Conclusions
References
Chapter 26: The role of plasticity in the recovery of consciousness
Abstract
The Boundaries of Consciousness
A Brief Clinical Overview on DOCs
Anatomical and Pathophysiologic Correlates of DOCs
Where and How Plastic Changes May Restore Consciousness: An Open Question
Interventions to Promote Plastic Changes for Consciousness Recovery in Prolonged DOCs
Concluding Remarks and Future Directions
Acknowledgments
References
Chapter 27: Plasticity of the language system in children and adults
Abstract
Introduction
Developmental Plasticity of Language
Language Plasticity after Developmental Brain Injury
Language Plasticity After Injury in Adults
Conclusions
Acknowledgments
References
Section VI: Inflammation, autoimmunity, and plasticity
Chapter 28: Synaptic dysfunction in early phases of Alzheimer’s Disease
Abstract
Introduction
A Quarter of a Century of the Amyloid Hypothesis
Amyloid and the Glutamatergic Synapse
Tau Pathology at the Synapse
Conclusions
References
Chapter 29: T cells, α-synuclein and Parkinson disease
Abstract
Introduction
Roles for α-Synuclein in PD
Implications of Aggregation and Accumulation for Autoimmunity
α-Syn Accumulation in Antigen Presenting Cells
The Enteric System and PD
Evidence of Altered Inflammatory Pathways in PD
Lymphocyte Roles in PD
A Role for MHC Proteins in PD Pathogenesis
A Connection Between Innate Immunity and Antigen Presenting Cells
α-Syn as an Autoimmune Neoantigen in PD
Implications for Diagnosis and Therapeutics
Summary
Acknowledgments
References
Chapter 30: Multiple sclerosis: Inflammation, autoimmunity and plasticity
Abstract
Introduction
Neuro-Immune Crosstalk in MS
Synaptic Inflammation in MS: Preclinical Studies
Synaptic Activity in Patients With MS
Synaptic Plasticity in Patients With MS
Synaptic Plasticity Expression and Clinical Recovery in MS
Inflammation Negatively Influences the Course of MS
Possible Approaches to Boost Synaptic Plasticity in MS
Conclusions
References
Section VII: Plasticity in cognitive and psychiatric disorders
Chapter 31: Alzheimer disease and neuroplasticity
Abstract
Introduction
Synaptic Dysfunction in AD
Neuroplasticity in AD
TMS to Measure Neuroplasticity in AD
TMS-Based Biomarkers in AD
TMS-Based Therapeutics in AD
Conclusions
References
Chapter 32: From chronic stress and anxiety to neurodegeneration: Focus on neuromodulation of the axon initial segment
Abstract
Introduction
Anxiety Control Within the Brainstem Modulatory Network: Projections to SN
Brainstem Modulatory Afferents and Vulnerability of SN Neurons to PD: Role of Chronic Stress
Stress-Induced Neuromodulation of SN’s Axon Initial Segment: A Risk Factor for Neurodegeneration
SN’s AIS Stem From Axon-Bearing Dendrites
Outlook
Acknowledgments
References
Chapter 33: Shaping plasticity with non-invasive brain stimulation in the treatment of psychiatric disorders: Present and future
Abstract
Summary
References

 

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