(Ebook PDF) Organofluorine Chemistry Synthesis and Applications 1st Edition by Prakash Reddy isbn 9780128132876 0128132876 full chapters

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ISBN 10:0128132876

ISBN 13:9780128132876

Author: V. Prakash Reddy

Organofluorine Chemistry: Synthesis and Applications gives a comprehensive outlook on modern synthetic methodologies for organofluorine compounds. It illustrates chemical, biochemical, and materials applications of fluorine-containing compounds, including synthesis and applications of small molecule compounds in drug discovery, positron emission tomography, and fluorinated polymers in solar cells. This book is of use to scientists working in the interdisciplinary areas, such as chemical, biochemical, and biomedical engineering, as well as those involved in materials science and medicinal chemistry. It is also a useful reference for researchers and graduate students interested in organofluorine chemistry.

• Provides modern synthetic methods and reactions of organofluorine compounds
• Incorporates the synthesis and chemical, biochemical and biomedical applications of fluorine-containing compounds, nanomaterials, PET imaging agents, pharmaceuticals, and polymeric materials
• Features emerging “hot” topics, such as late-stage fluorinations and drug discovery

Table of Contents:

• 1. Nucleophilic reactions in the synthesis of organofluorine compounds
• Abstract
• Chapter Outline
• 1.1 Introduction
• 1.2 Reagents for nucleophilic fluorinations
• 1.3 Nucleophilic deoxyfluorination
• 1.4 Nucleophilic fluorination of pyridines and diazines
• 1.5 Nucleophilic gem-difluorination of carbonyl compounds
• 1.6 Nucleophilic fluoroalkylations
• 1.7 Nucleophilic trifluoromethylthiolation
• 1.8 Trifluoromethoxylations
• References
• 2. Electrophilic reactions in the synthesis of organofluorine compounds
• Abstract
• Chapter Outline
• 2.1 Introduction
• 2.2 Reagents for electrophilic fluorination
• 2.3 Enantioselective electrophilic fluorination
• 2.4 Electrophilic fluorination in the synthesis of α-fluorinated amino acids
• 2.5 Electrophilic fluoroalkylation
• 2.6 Electrophilic trifluoromethylthiolation and trifluoromethoxylation
• 2.7 Synthetic methods for trifluoromethylthiolation
• 2.8 Difluoromethylthiolation
• References
• 3. Free-radical reactions in the synthesis of organofluorine compounds
• Abstract
• Chapter Outline
• 3.1 Introduction
• 3.2 Reagents for the free-radical trifluoromethylation
• 3.3 Decarboxylative fluoroalkylation
• 3.4 β-Amino-fluoroalkylation of alkenes
• 3.5 Fluoroalkylation using sodium triflinate (Langlois reagent)
• 3.6 Photoredox-catalyzed S-fluoroalkylation and arylation
• 3.7 Radical fluoroalkylation of enolates
• References
• 4. Organotransition metal catalysis in the synthesis of organofluorine compounds
• Abstract
• Chapter Outline
• 4.1 Introduction
• 4.2 Pd-catalyzed fluorination of aryl halides and triflates
• 4.3 Transition metal–catalyzed C–H fluorination
• 4.4 Au(I)-catalyzed hydrofluorination of alkenes and alkynes
• 4.5 Ni-catalyzed fluoroalkylation of aromatics
• 4.6 Ag(II)-catalyzed oxidative ring-opening fluorination of cyclic amines
• 4.7 Ag(I)-catalyzed decarboxylative fluorination
• 4.8 Cu(I)-mediated dediazoniative difluoromethylation
• 4.9 Fluoroalkylation of arylboronic acids and esters
• 4.10 Cu(I)-catalyzed fluoroalkylation of aryl halides
• 4.11 Ni-catalyzed trifluoromethylthiolation
• 4.12 Pd(II)-catalyzed (amino)trifluoromethoxylation
• References
• 5. Pharmaceutical applications of organofluorine compounds
• Abstract
• Chapter Outline
• 5.1 Introduction
• 5.2 Antibacterial pharmaceuticals
• 5.3 Antidiabetic pharmaceuticals
• 5.4 Anti-Alzheimer pharmaceuticals
• 5.5 Anti-HIV pharmaceuticals
• 5.6 Antimalarial pharmaceuticals
• 5.7 Anticancer pharmaceuticals
• 5.8 Antiviral pharmaceuticals
• 5.9 Fluorinated pharmaceuticals for cardiovascular diseases
• 5.10 Antiinflammatory pharmaceuticals
• 5.11 Antidepressants
• References
• 6. Synthesis and applications of 18F-labeled compounds
• Abstract
• Chapter Outline
• 6.1 Introduction
• 6.2 Synthetic methods for radiofluorination
• 6.3 Sharpless click reactions for positron emission tomography tracers
• 6.4 Staudinger ligation reactions for positron emission tomography tracers
• 6.5 Radiofluorination via aromatic nucleophilic substitution
• 6.6 Transition metal–mediated radiofluorination
• 6.7 Radiofluorination via diaryliodonium salts
• 6.8 Enzymatic fluorination reactions for [18F]-labeled positron emission tomography tracers
• 6.9 Positron emission tomography tracers in Alzheimer’s disease
• 6.10 18F-positron emission tomography tracers in cancer diagnosis
• References
• 7. Materials applications of organofluorine compounds
• Abstract
• Chapter Outline
• 7.1 Introduction
• 7.2 Fluorinated surfactants
• 7.3 Fluoropolymers
• 7.4 Fluorinated π-conjugated polymeric materials in photovoltaic devices
• 7.5 Fluorinated poly(aryl thioethers) in organic electronic materials
• 7.6 Polymer electrolytes
• 7.7 Fluorinated ionomers as proton-exchange membranes in fuel cells
• 7.8 Fluorinated carbon nanoparticles and nonaqueous electrolytes in lithium- and lithium-ion batteries
• 7.9 Fluorinated hyperbranched dendrimers: synthesis and applications
• 7.10 Fluorinated compounds in drug delivery and magnetic resonance imaging
• 7.11 Organofluorine liquid crystal materials
• 7.12 Organofluorine compounds in high-energy materials

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Prakash Reddy,Organofluorine Chemistry,Synthesis,Applications