Pharmacology and Toxicology of Cytochrome P450 60th Anniversary 1st Edition by Hiroshi Yamazaki 9780323911108

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ISBN-13 ‏ : ‎9780323911108

Author:   Hiroshi Yamazaki 

Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary, Volume 95 highlights the extensive contributions by worldwide researchers in the cytochrome P450 (P450) field over the past six decades, and since the first article on P450 was published in 1962. Chapters in this new release include Multiple conformations of cytochromes P450 and the relevance to predicting SAR, Pharmacogenetics of the cytochromes P450 and relevance to drug metabolism, Cytochromes P450 drug metabolism within the brain, Mammalian cytochrome P450 biodiversity: Physiological importance, function, and protein and genomic structures of cytochromes P4502B in multiple species of woodrats with different dietary preferences, and more.

Additional section cover Atypical kinetics of cytochrome P450 enzymes in drug metabolism, Biosynthesis using cytochrome P450 Enzymes: focus on synthesis of drug metabolites, Use of engineered cytochrome P450s for accelerating drug discovery and development, Assessing cytochrome P450 function using genetically engineered mouse models, Use of the biologicals with sustainable reproducibility for phenotyping study of cytochrome P450 enzymes involved in the biotransformation of test compounds and calculating the fraction unbound parameter, for anticipating drug Interactions, and much more.

 

Pharmacology and Toxicology of Cytochrome P450 – 60th Anniversary 1st Table of contents:

1. Roles of cytochrome P450 enzymes in pharmacology and toxicology: Past, present, and future
F. Peter Guengerich

2. Pharmacogenetics of the cytochromes P450: Selected pharmacological and toxicological aspects
Ann K. Daly

3. Cytochromes P450 and metabolism of drugs and neurotoxins within the mammalian brain
Marlaina R. Stocco and Rachel F. Tyndale

4. Mammalian cytochrome P450 biodiversity: Physiological importance, function, and protein and genomic structures of cytochromes P4502B in multiple species of woodrats with different dietary preferences
Michele M. Skopec, James R. Halpert and M. Denise Dearing

5. Atypical kinetics of cytochrome P450 enzymes in pharmacology and toxicology
Jacqueline Wen Hui Leow, Lloyd Wei Tat Tang and Eric Chun Yong Chan

6. Biosynthesis using cytochrome P450 enzymes: Focus on synthesis of drug metabolites
W. Griffith Humphreys

7. Use of engineered cytochrome P450s for accelerating drug discovery and development
Raine E.S. Thomson, Stephlina A. D’Cunha, Martin A. Hayes and Elizabeth M.J. Gillam

8. Assessing cytochrome P450 function using genetically engineered mouse models
Sarrah Hannon and Xinxin Ding

9. Expressions and functional activities of cytochrome P450 enzymes in human hepatocytes having sustainable reproducibility for in vitro phenotyping study
Pamela Bachour-El Azzi, Christophe Chesné and Shotaro Uehara

10. Cytochrome P450s in chimeric mice with humanized liver
Shotaro Uehara, Hiroshi Suemizu and Hiroshi Yamazaki

11. Polymorphic cytochromes P450 in non-human primates
Yasuhiro Uno, Shotaro Uehara and Hiroshi Yamazaki

12. Cytochrome P450 enzymes in the pediatric population: Connecting knowledge on P450 expression with pediatric pharmacokinetics
Chie Emoto and Trevor N. Johnson

13. Cytochrome P450 polymorphism: From evolution to clinical use
Magnus Ingelman-Sundberg

 

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Tags: Pharmacology, Toxicology, Cytochrome, Anniversary, Hiroshi Yamazaki