Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations 2nd Edition

Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations 2nd Edition – Ebook Instant Download/Delivery ISBN(s): 9781119497684,9781119497769,9781119497790,9781119497813,111949768X,1119497760,1119497795,1119497817

Product details:

• ISBN-10: 1119497795
• ISBN-13: 9781119497790
• Author: Sheila Annie Peters 

Now in its second edition, Physiologically Based Pharmacokinetic (PBPK) Modelling and Simulations: Principles, Methods, and Applications in the Pharma Industry remains the premier reference book throughout the rapidly growing PBPK user community. Using clear and concise language, author Sheila Annie Peters connects theory with practice as she explores the vast potential of PBPK modeling for improving drug discovery and development.

Table contents:

Section I. Principles, Methods, andBackground Information

1 A Review of Pharmacokinetic and Pharmacodynamic Principles

2 A Review of Drug–Drug Interactions

3 Modeling Pharmacokinetics, Pharmacodynamics, And Drug Interactions

4 Physiological Model For Absorption

5 Physiological Model For Distribution

6 Physiological Models For Drug Metabolism And Excretion

7 Generic Whole-Body Physiologically Based Pharmacokinetic Modeling

8 Pbpk Modeling Of Biotherapeutics

9 Uncertainty And Population Variability

10 Nonclinical, Clinical, and Model-Informed Drug Development

Section II. Applications In The Pharmaceutical Industry

11 Overview Of Pbpk Applications

12 Applications Of Hypothesis Generation And Testing With Pbpk Models

13 Applications of Physiologically Based Pharmacokinetic Models Integrated With Drug Effect Models (Pbpk/Pd)

14 Pbpk Modeling and Simulations to Evaluate Clinical Drug-Drug Interactions

15 Dose Extrapolation Across Populations (Healthy Adult Caucasian To Pediatric, Pregnant Women, Different Ethnicities, Geriatric, Smokers And Obese Populations)

16 Dose Extrapolation Across Populations: Healthy Adult To Hepatic And Renal Impairment Populations

17 Absorption-Related Applications Of Pbpk Modeling

18 Regulatory Guidelines On The Reporting Of Physiologically Based Pharmacokinetic (Pbpk) Modeling Analysis

19 Resolving The Challenges To Establishing Confidence In Pbpk Models

20 Epilogue

Section III. Case Studies Of Pbpk Applications In The Pharmaceutical Industry

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