Phytochemicals as Lead Compounds for New Drug Discovery Prospects for Sustainable Agriculture 1st Edition by Chukwuebuka Egbuna 0128178914 9780128178911

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ISBN-10 :  0128178914 

ISBN-13 :  9780128178911

Author :  Chukwuebuka Egbuna 

Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases.

Phytochemicals as Lead Compounds for New Drug Discovery: Prospects for Sustainable Agriculture 1st Table of contents:

Part I. Plants as natural sources of drugs
Chapter 1. Plant secondary metabolites as lead compounds for the production of potent drugs
1.1. Medicinal plants and phytochemicals
1.2. Conclusion
Chapter 2. Factors affecting the choice for plant-based products in drug discoveries
2.1. Introduction
2.2. Conclusion
Chapter 3. Advances in computer-aided drug discovery
3.1. Introduction
Chapter 4. FDA drug candidacy acceptance criteria and steps: problems and way forward
4.1. Introduction
Part II. Biofunctional leads for drug development
Chapter 5. Bioactive lead compounds and molecular targets for the treatment of heart diseases
5.1. Introduction
5.2. Natural products targeting autophagy and cardiovascular disorders
5.3. Natural products targeting endoplasmic reticulum (ER) and cardiovascular diseases
5.4. Atherosclerosis and chronic inflammation
5.5. Selected classes of natural products used in the prevention of hypertension and ischaemic heart diseases by various mechanisms
5.6. Natural products in preclinical/clinical studies
Chapter 6. Natural bioactive lead compounds effective against haematological malignancies
6.1. Introduction
Chapter 7. Adjunct therapeutic potential of phytochemicals against cancer
7.1. Introduction
Chapter 8. Antidiabetic lead compounds and targets for drug development
8.1. Introduction
8.2. Molecular targets of antidiabetic drugs
8.3. Phytochemicals in diabetes management
8.4. Classes of antidiabetic drugs currently used
8.5. Antidiabetic drugs on clinical trial
8.6. Future directions
8.7. Conclusion
Chapter 9. Antiobesity functional leads and targets for drug development
9.1. Introduction
Chapter 10. Phytochemicals as therapeutic interventions in neurodegenerative diseases
10.1. Introduction
Chapter 11. Organosulfur phytochemicals against metabolic and neurodegenerative diseases: benefits and risks
11.1. Introduction to phytochemicals: chemistry and classification
Chapter 12. Lead compounds with the potentials for the treatment of chronic liver diseases
12.1. Introduction
Chapter 13. Bioactive lead compounds effective against skin diseases
13.1. Introduction
Chapter 14. Phytochemicals as emerging therapeutic agents for alopecia treatment
14.1. Introduction
Chapter 15. Antiviral phytocompounds for drug development: a data mining studies
15.1. Introduction
Chapter 16. Shikimic acid as intermediary model for the production of drugs effective against influenza virus
16.1. Introduction
16.2. Influenza and its various forms
Chapter 17. Antimicrobial lead compounds from marine plants
17.1. Introduction
Chapter 18. Antibacterial lead compounds and their targets for drug development
18.1. Introduction
Chapter 19. Awareness and current therapeutic strategies of malaria
19.1. Introduction
Chapter 20. Bioactive lead compounds and targets for the development of antimalarial drugs
20.1. Introduction
20.2. Conclusion
Chapter 21. Bioactive lead compounds and molecular targets for the development of antiinflammatory drugs
21.1. Introduction
Chapter 22. Functional lead compounds and targets for the development of drugs for the treatment of male infertility
22.1. Introduction
Chapter 23. Prenylated flavonoids as a promising drug discovery candidate: a pharmacological update
23.1. Introduction

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Phytochemicals,Lead Compounds,New Drug Discovery,Prospects,Sustainable Agriculture,Chukwuebuka Egbuna