Quantitative systems pharmacology : models and model-based systems with applications 1st Edition Davide Manca

Quantitative systems pharmacology : models and model-based systems with applications – Ebook Instant Download/Delivery ISBN(s): 9780444639646,0444639640

Product details:

• ISBN-10 ‏ : ‎ 0444639640
• ISBN-13 ‏ : ‎ 978-0444639646
• Author(s): Davide Manca

Quantitative Systems Pharmacology: Models and Model-Based Systems with Applications, Volume 42, provides a quantitative approach to problem-solving that is targeted to engineers. The book gathers the contributions of doctors, pharmacists, biologists, and chemists who give key information on the elements needed to model a complex machine like the human body. It presents information on diagnoses, administration and release of therapeutics, distribution metabolism and excretion of drugs, compartmental pharmacokinetics, physiologically-based pharmacokinetics, pharmacodynamics, identifiability of models, numerical methods for models identification, design of experiments, in vitro and in vivo models, and more.

As the pharma community is progressively acknowledging that a quantitative and systematic approach to drug administration, release, pharmacokinetics and pharmacodynamics is highly recommended to understand the mechanisms and effects of drugs, this book is a timely resource.

Table contents:

Section 1: Introduction to Quantitative Systems Pharmacology
Chapter 1: Quantitative systems pharmacology: Extending the envelope through systems engineering
Section 2: Modeling and Applications of Systemic Pharmacokinetics and Pharmacodynamics
Chapter 2: An engineering oriented approach to physiologically based pharmacokinetic and pharmacodynamic modeling
Chapter 3: Advanced Techniques for the Optimal Design of Experiments in Pharmacokinetics
Chapter 4: On the Identifiability of Physiological Models: Optimal Design of Clinical Tests
Chapter 5: Bayesian hierarchical modeling of gabapentin absorption and disposition with application to dosing regimen assessment
Chapter 6: Computational tools in the assistance of personalized healthcare
Section 3: Transport and Distribution of Drugs to Target Sites
Chapter 7: Multiscale models for transport and biodistribution of therapeutics in cancer
Chapter 8: Quantitative systems pharmacology on cancer drug delivery to target sites: Application of chemical engineering tools
Chapter 9: Systems engineers’ role in biomedical research. Convection-enhanced drug delivery
Section 4: Modeling of Drug Delivery Systems
Chapter 10: On the modeling of oral drug delivery
Chapter 11: Drug delivery from polymeric matrices
Chapter 12: Modeling the mechanics and the transport phenomena in hydrogels
Index

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