Retrosynthesis in the Manufacture of Generic Drugs Pedro Paulo Santos

Retrosynthesis in the Manufacture of Generic Drugs – Ebook Instant Download/Delivery ISBN(s): 9781119155539,1119155533

Product details:

• ISBN-10 ‏ : ‎ 1119155533
• ISBN-13 ‏ : ‎ 978-1119155539
• Author: Pedro Paulo Santos

This book illustrates how the retrosynthetic tool is applied in the Pharmaceutical Industry. It considers and evaluates the many viable synthetic routes that can be used by practicing industrialists, guiding readers through the various steps that lead to the “best” processes and the limits encountered if these are put into practice on an industrial scale of seven key Active Pharmaceutical Ingredient (API). It presents an evaluation of the potential each process has for implementation, before merging the two points of view—of retrosynthesis and process chemistry—in order to show how retrosynthetic analysis assists in selecting the most efficient route for an industrial synthesis of a particular compound whilst giving insight into the industrial process. The book also uses some key concepts used by process chemists to improve efficiency to indicate the best route to select.

Table contents:

1 INTRODUCTION

2 GABAPENTIN

3 CLOPIDOGREL

4 CITALOPRAM AND ESCITALOPRAM

5 SITAGLIPTIN

6 EZETIMIBE

7 MONTELUKAST

8 OSELTAMIVIR

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