(Ebook PDF) Studies in natural products chemistry Volume 58 Bioactive natural products 1st edition by Atta ur Rahman 9780444640598 full chapters

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ISBN-13 :  9780444640598

Author :  Atta-ur-Rahman 

Studies in Natural Products Chemistry, Volume 58, covers the synthesis, testing and recording of the medicinal properties of natural products, providing cutting edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to rapidly isolate and determine the structures and biological activity of natural products, thus opening up exciting opportunities in the field of new drug development in the pharmaceutical industry.

Studies in natural products chemistry. Volume 58. Bioactive natural products 1st Table of contents:

Chapter 1. Synthesis and Structure–Activity Relations in Allylsulfide and Isothiocyanate Compounds From Garlic and Broccoli Against In Vitro Cancer Cell Growth
Background
Garlic
The Cytotoxicity of Garlic Allylsulfur Compounds in Cancer Cells
Synthetic Routes to Garlic Allylsulfur Compounds and Their Derivatives
Structure–Activity Relations of Garlic Allylsulfides Against In Vitro Cancer Cell Growth
Broccoli
The Cytotoxicity of Broccoli Isothiocyanates in Cancer Cells
Synthetic Routes to Broccoli Isothiocyanates and their Derivatives
Structure–Activity Relations of Isothiocyanates Against In Vitro Cancer Cell Growth
Commonality in the Anticancer Mechanisms of Isothiocyanates and Polysulfides in Cancer Cells
Conclusion
Chapter 2. Natural Products as Lead Protein Kinase C Modulators for Cancer Therapy
Introduction
Isoforms of Protein Kinase C Family
Phorbol Esters
Bryostatins
Staurosporine Analogs
Ingenene Diterpenes
Miscellaneous and Promising Agents
Concluding Remarks
Chapter 3. Plant-Derived Prooxidants as Potential Anticancer Therapeutics
Introduction
Types of Reactive Oxygen Species Causing Oxidative Stress
Sources of Cellular Reactive Oxygen Species
Physiological Role(s) of Reactive Oxygen Species
Attenuation of Oxidative Stress by Antioxidants
Modulation of Reactive Oxygen Species and the Pathogenesis of Cancers
Prooxidants as Potential Anticancer Compounds
Impact of Prooxidants Upon Oxidative Stress-Related Signaling Events
How Do Prooxidants Regulate the Signaling Pathways?
Concluding Remarks
Chapter 4. Anticancer and Antineurodegenerative Effects of Ginsenosides
Introduction
Anticarcinogenic Function of Ginseng
Protective Function of Ginseng Against Neurodegenerative Diseases
Summary and Further Research
Chapter 5. Role of Phytochemicals in MAPK Signaling Pathway-Mediated Apoptosis: A Possible Strategy in Cancer Chemoprevention
Introduction
MAPK Signal Transduction Pathways
Conclusion
Abbreviations
Chapter 6. Natural Products as Cathepsin Inhibitors
Introduction
First Cathepsins Inhibitors
E-64 and Derivatives
Miraziridine A
Tokaramide A
Gallinamide A/Symplostatin 4
Grassypeptolides
Cyclohexenyl Inhibitors
Benzophenone Inhibitors
Ursolic Acid
Flavonoids
Flavonoids and Triterpenes as Parasitic Cathepsin L Inhibitors
Acridones as Cathepsin V Inhibitors
Grassystatins as Cathepsin D and E Inhibitors
Inhibitors of Cathepsin K
Summary
Chapter 7. Endemic Plants of Italy and Their Peculiar Molecular Pattern
Introduction
Endemism
Biodiversity
Chapter 8. From Natural Products to Drugs: Glyco- and Lipoglycopeptides, a New Generation of Potent Cell Wall Biosynthesis Inhibitors
Introduction
The Glycopeptide Family
The Lipoglycopeptide Family
Conclusion and Outlooks
Abbreviations
Chapter 9. CH Bond Activation as a Powerful Tool in the Construction of Biologically Active Nitrogen-Containing Heterocycles
Introduction
Five-Membered N-Heterocycles
Six-Membered N-Heterocycles
Small and Large N-Heterocycles
Summary and Outlook
Abbreviations
Chapter 10. Isolation, Bioactivity, and Synthesis of Nagelamides
Introduction
Biosynthetic Considerations
Synthetic Studies Toward the Nagelamides
Synthetic Studies to Nagelamide Fragments
Conclusions
Abbreviations
Chapter 11. Nutraceuticals Neuroprotect Naturally: Alzheimer’s disease, Parkinson’s disease, Stroke and Major Depressive Disorder
Introduction
Alzheimer’s Disease
Parkinson’s Disease
Stroke
Major Depressive Disorder
Chapter 12. Nanotechnology-Based Approach for Enhanced Bioavailability and Stability of Tea Polyphenols—A Review
Introduction
Biosynthesis of Catechins
Health Benefits of Tea
Limitations of Tea Polyphenols
Strategy to Overcome the Limitations
Nanoencapsulation of Green Tea Polyphenols

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