(Ebook PDF) The Wolff Kishner Reduction and Related Reactions Discovery and Development 1st Edition by David E. Lewis –Ebook PDF Instant Download/Delivery:9780128165201, 0128165200
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Product details:
ISBN 10: 0128165200
ISBN 13: 9780128165201
Author: David E. Lewis
Table of contents:
Chapter 1: The Discoverers of the Reaction
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Abstract
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Nikolai Matveevich Kizhner: A Truly Eventful Life (4, 5)
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Ludwig Wolff (49)
Chapter 2: Discovery and Priority
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Abstract
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1911–1913: Kizhner’s Initial Disclosures of the Reaction
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1911: Wolff’s Version of the Reaction
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Settling the Question of Priority
Chapter 3: Early Studies of the Reaction
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Abstract
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Mechanistic Investigations
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Pyrazolines and N-alkylhydrazones
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Side Reactions in the Wolff-Kishner Reduction
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Early Exploration of the Scope and Limitations of the Reaction
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Higher Terpenoids and Steroids
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Heterocyclic Compounds and Alkaloids
Chapter 4: The Huang-Minlon Modification
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Abstract
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Introduction
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The Huang-Minlon Modification of the Wolff-Kishner Reduction
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Representative Applications of the Huang-Minlon Method
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Limitations of the Wolff-Kishner Reduction
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A Final Word…
Chapter 5: Modern Adaptations of the Wolff-Kishner Reduction
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Abstract
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Introduction
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Effects of Steric Hindrance on the Wolff-Kishner Reaction
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Barton and Nagata Modifications of the Wolff-Kishner Reduction: “Forced” Wolff-Kishner Reductions
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What About Not Using a Base at All? Deoxygenation by Reduction of Sulfonylhydrazones
Chapter 6: Kishner Reduction-Elimination of α-Substituted Ketones
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Abstract
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Introduction
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Reduction of α-amino-, α-alkoxy-, and α-hydroxyketones
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The Reaction of Epoxyketones and 2-acylaziridines with Hydrazine: The Wharton and Aza-Wharton Reactions
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The Reaction of Epoxyketones with Tosylhydrazine: The Eschenmoser Fragmentation
Chapter 7: Deoxygenation in Modern Synthesis
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Abstract
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Introduction
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The Huang-Minlon Modification
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The Barton Modification
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The Nagata Modification
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The Wharton and Aza-Wharton Reactions
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The Eschenmoser Fragmentation
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The Shapiro Reaction
Index
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