Validamycin and its Derivatives. Discovery, Chemical Synthesis, and Biological Activity 1st Edition Edition Xiaolong Chen

Validamycin and its Derivatives. Discovery, Chemical Synthesis, and Biological Activity 1st Edition Edition Xiaolong Chen – Ebook Instant Download/Delivery ISBN(s): 9780081011133,008101113X, 9780081011133

Product details:

• ISBN 13: 9780081011133
• Author: Xiaolong Chen, Yuele Lu, Yongxian Fan, Yinchu Shen

Validamycin and Its Derivatives: Discovery, Chemical Synthesis and Biological Activity presents, for the first time, a complete review of the underlying chemistry, synthesis, behavior and application of these compounds.Beginning with an introduction to validamycin, the book then outlines the key elements of its discovery and production, including details of its structures, isolation, analysis, and issues relating to its large scale production.Biological activities are then explored in more detail, followed by details of biosynthesis. Further to this, the chemical synthesis of validamycin and its intermediates, including valienamine, validamine, valiolamine, and validoxylamines is reviewed, before preparation of these derivatives and their biological activities are explored.Finally, the book concludes with a discussion of the economic aspects of working with validamycin and its potential in future applications and trends. With its detailed chemical coverage from a team of expert authors, this detailed guide can be applied to the large-scale industrial production of antibiotics and the adaptation of bioactive agents, from agricultural, to novel pharmaceutical applications

Table contents:

Chapter 1. An Introduction to Validamycins and Their Derivatives

Chapter 2. Production of Validamycins

Chapter 3. Bioactivities of Validamycins and Related Natural Compounds

Chapter 4. Chemical Synthesis of Validamycin and Related Natural Compounds

Chapter 5. Voglibose: An Important Drug for Type 2 Diabetes

Chapter 6. N-Octyl-β-Valienamine and N-Octyl-4-epi-β-Valienamine: Two Highly Potent Drug Candidates for Chemical Chaperone Therapy

Chapter 7. Prospects and Concluding Remarks

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